The Influence of Embryonal Bursectomy on Benzpyrene-induced Sarcoma of the Chicken

Overview

Journal Z Krebsforsch Klin Onkol Cancer Res Clin Oncol

Specialty Oncology

Date 1978 Jan 1

PMID 151398

Citations 1

Authors

H R NIEDORF

A Lusznat

E Hultsch

E Grundmann

Affiliations

Soon will be listed here.

Abstract

160 chickens hormonally bursectomized before hatching, and 160 controls were twice given a dose of 10 mg 3,4-benzo(a)pyrene 2 weeks and 6 weeks after hatching. After 24 weeks the controls had developed muscle sarcomas at a significantly higher rate than the bursectomized animals (49.6--32.1%). The tumors were identified as malignant polymorphocellular rhabdomyosarcomas in light and electron microscopy. When the experiment was stopped after 27 weeks, the controls showed more tumors than the bursectomized chickens (65.1% versus 58.9%). The effect of bursectomy lies in a prolongation fo tumor latency. The frequency of metastases is equally decreased to a significant degree (41.7% versus 21.7%). These results are interpreted as an illustration of the disturbed equilibrium between the T and B cell responses.

Citing Articles

[Mechanisms of malignant growth (author's transl)].

Grundmann E Klin Wochenschr. 1981; 59(17):931-41.

PMID: 7289441 DOI: 10.1007/BF02310968.

References

Warner N . Membrane immunoglobulins and antigen receptors on B and T lymphocytes. Adv Immunol. 1974; 19(0):67-216. DOI: 10.1016/s0065-2776(08)60252-7. View

Cooper M, Cain W, VAN ALTEN P, GOOD R . Development and function of the immunoglobulin producing system. I. Effect of bursectomy at different stages of development on germinal centers, plasma cells, immunoglobulins and antibody production. Int Arch Allergy Appl Immunol. 1969; 35(3):242-52. View

Payne L, Rennie M . Lack of effect of bursectomy on Marek's disease. J Natl Cancer Inst. 1970; 45(2):387-97. View

Carpenter C, dApice A, Abbas A . The role of antibodies in the rejection and enhancement of organ allografts.?7318. Adv Immunol. 1976; 22:1-65. DOI: 10.1016/s0065-2776(08)60547-7. View

Herberman R . Cell-mediated immunity to tumor cells. Adv Cancer Res. 1974; 19(0):207-63. DOI: 10.1016/s0065-230x(08)60055-x. View

Linna T, Hu C, K D Thompson . Development of systemic and local tumors induced by avian reticuloendotheliosis virus after thymectomy or bursectomy. J Natl Cancer Inst. 1974; 53(3):847-54. DOI: 10.1093/jnci/53.3.847. View

Fujimoto Y, Okada K, Okada M . Rhabdomyosarcoma in the chicken. Jpn J Vet Res. 1970; 18(3):109-15. View

Linna T, Frommel D, GOOD R . Effects of early cyclophosphamide treatment on the development of lymphoid organs and immunological functions in the chickens. Int Arch Allergy Appl Immunol. 1972; 42(1):20-39. DOI: 10.1159/000230590. View

Cooper M, Lawton A, Kincade P . A two-stage model for development of antibody-producing cells. Clin Exp Immunol. 1972; 11(1):143-9. PMC: 1553675. View

10.

Danielson J, VAN ALTEN P . Lymphocyte proliferation inhibited by cells and by effector substances obtained from bursal lymphocytes. Prog Exp Tumor Res. 1974; 19:194-202. DOI: 10.1159/000395856. View

11.

Saal J, Rieber E, Hadam M, Riethmuller G . Lymphocytes with T-cell markers cooperate with IgG antibodies in the lysis of human tumour cells. Nature. 1977; 265(5590):158-60. DOI: 10.1038/265158a0. View

12.

McArthur W, CARSWELL E, Thorbecke G . Growth of Rous sarcomas in bursectomized chickens. J Natl Cancer Inst. 1972; 49(3):907-9. View

13.

Thomas C, Steinhardt H, Kuchemann K, MAAS D, Riede U . Soft tissue tumors in the rat. Pathogenesis and histopathology. Curr Top Pathol. 1977; 64:129-76. DOI: 10.1007/978-3-642-66581-3_3. View

14.

Riede U, Thomas C, Sandritter W . [Ultrastructural study on formal pathogenesis of experimentally induced rhabdomyosarcomas (author's transl)]. Exp Pathol (Jena). 1977; 13(2-3):162-74. View

15.

Wolters B, Hultsch E, NIEDORF H . Bursa-independent plasma cells in the Harderian gland of the chicken (Gallus domesticus). Histomorphometrical investigations. Beitr Pathol. 1977; 160(1):50-7. DOI: 10.1016/s0005-8165(77)80005-x. View

16.

Lifter J, Kincade P, Choi Y . Subpopulations of chicken B lymphocytes. J Immunol. 1976; 117(6):2220-5. View

17.

Sato K, Abe S . The possible presence of a bursa-independent, IgM-producing system in chicks. Immunology. 1975; 28(2):293-9. PMC: 1445797. View

18.

Nossal G . Principles of immunological tolerance and immunocyte receptor blockade. Adv Cancer Res. 1974; 20:93-130. DOI: 10.1016/s0065-230x(08)60109-8. View

19.

Brand A, Gilmour D, Goldstein G . Lymphocyte-differentiating hormone of bursa of fabricius. Science. 1976; 193(4250):319-21. DOI: 10.1126/science.180600. View

20.

Morris J, Jerome FNREINHART B . Surgical bursectomy and the incidence of Marek's disease (MD) in domestic chickens. Poult Sci. 1969; 48(4):1513-5. DOI: 10.3382/ps.0481513. View