MicroRNA Precursors in Motion: Exportin-5 Mediates Their Nuclear Export

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2004 May 12

PMID 15134074

Citations 112

Authors

V Narry Kim

Affiliations

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Abstract

The discovery of microRNSs (miRNAs) has changed the paradigm of gene regulation, leaving us with numerous exciting questions regarding what these molecules do and how they originate. A model for miRNA biogenesis has emerged recently, yet several key factors--including the identity of the miRNA nuclear export receptor--remained unknown. However, recent studies have shown that exportin-5 (Exp5), a Ran-dependent importin-beta-related transport receptor, mediates nuclear export of miRNA precursors (pre-miRNAs).

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