Overexpression of Annexin 1 in Pancreatic Cancer and Its Clinical Significance

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2004 May 11

PMID 15133855

Citations 86

Authors

Xiao-Feng Bai

Xiao-Guang Ni

Ping Zhao

Shang-Mei Liu

Hui-Xin Wang

Bing Guo

Lan-Ping Zhou

Fang Liu

Jin-Sheng Zhang

Kun Wang

Yong-Qiang Xie

Yong-Fu Shao

Xiao-Hang Zhao

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the expression of annexin I in pancreatic cancer and its relationship with the clinicopathologic factors, and to evaluate its potential clinical significance.

Methods: Annexin I expression was analyzed by Western blot and immunohistochemical staining in pancreatic adenocarcinoma and multi-tissue microarrays (MTAs).

Results: Western blot analysis showed that annexin I was overexpressed in 84.6% (11/13) pancreatic ductal adenocarcinomas. Immunohistochemistry analysis of pancreatic cancer in MTAs showed that annexin I protein was 71.4%(30/42) positive which was markedly increased compared with that in the tumor matched normal pancreas tissues 18.4%(7/38) (P<0.01). In the meantime, the high expression of annexin 1 was correlated with the poor differentiation of pancreatic adenocarcinoma.

Conclusion: Annexin 1 overexpression is a frequent biological marker and correlates with the differentiation of pancreatic cancer during tumorigenesis.

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