The Influence of Parasitism on the Pharmacokinetics of Moxidectin in Lambs

Overview

Journal Parasitol Res

Specialty Parasitology

Date 2004 May 6

PMID 15127292

Citations 8

Authors

Anne Lespine

Jean-Francois Sutra

Jacques Dupuy

Michel Alvinerie

Gilles Aumont

Affiliations

Soon will be listed here.

Abstract

Most pharmacokinetic studies on anthelmintic drugs have been performed on non-parasitized animals. However, it seems likely that the parasite burden could influence the deposition of such drugs. The pharmacokinetics of moxidectin administered orally and by subcutaneous injection was compared in lambs exposed to nematode infection and in parasite naive lambs. Plasma samples were analyzed for moxidectin over 40 days post-treatment. The main pharmacokinetic parameters calculated demonstrated a significant change in drug deposition in infected lambs when compared to controls. The area under the plasma concentration-time curve was decreased 54% and 46% by infection in the subcutaneous and oral groups, respectively. There was also a major decrease in the mean residence time in parasitized lambs. In parallel, the clearance of the drug was increased by infection. Thus, parasite infection dramatically influences the disposition of moxidectin in lambs. These results may contribute to determining a therapeutic strategy adapted to heavily infested animals.

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