Mechanisms for Regulation of Hsp70 Function by Hsp40

Overview

Journal Cell Stress Chaperones

Publisher Elsevier

Specialty Cell Biology

Date 2004 Apr 30

PMID 15115283

Citations 137

Authors

Chun-Yang Fan

Soojin Lee

Douglas M Cyr

Affiliations

Soon will be listed here.

Abstract

The Hsp70 family members play an essential role in cellular protein metabolism by acting as polypeptide-binding and release factors that interact with nonnative regions of proteins at different stages of their life cycles. Hsp40 cochaperone proteins regulate complex formation between Hsp70 and client proteins. Herein, literature is reviewed that describes the mechanisms by which Hsp40 proteins interact with Hsp70 to specify its cellular functions.

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