The Developing Cholinergic System As Target for Environmental Toxicants, Nicotine and Polychlorinated Biphenyls (PCBs): Implications for Neurotoxicological Processes in Mice

Overview

Journal Neurotox Res

Publisher Springer

Specialty Neurology

Date 2004 Apr 28

PMID 15111260

Citations 12

Authors

P Eriksson

E Ankarberg

H Viberg

A Fredriksson

Affiliations

Soon will be listed here.

Abstract

During neonatal life, offspring can be affected by toxic agents either by transfer via mother's milk or by direct exposure. In many mammalian species the perinatal period is characterized by a rapid development of the brain - "the brain growth spurt" (BGS). This period in the development of the mammalian brain is associated with numerous biochemical changes that transform the feto-neonatal brain into that of the mature adult. In rodents, the cholinergic transmitter system undergoes a rapid development during the neonatal period, a time when spontaneous motor behaviour also reaches peak activity. We have observed that low-dose exposure to environmental toxicants such as nicotine, polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDE, flame retardants) during the "BGS" can lead to irreversible changes in adult brain function in the mouse. The induction of persistent effects on behaviour and cholinergic nicotinic receptors in the adult animal appears to be limited to a short period during neonatal development. Furthermore, the neurotoxic effects were shown to develop over time, indicating a time-response/time-dependent effect. This indicates that environmental toxicants, such as nicotine, PCBs and probably PBDEs, might be involved in the slow, implacable induction of neurodegenerative disorders and/or interfere with normal aging processes.

Citing Articles

Neurotoxicity of Combined Exposure to the Heavy Metals (Pb and As) in Zebrafish ().

Liu M, Deng P, Li G, Liu H, Zuo J, Cui W Toxics. 2024; 12(4).

PMID: 38668505 PMC: 11054020. DOI: 10.3390/toxics12040282.

Developmental Neurotoxicity of Trichlorfon in Zebrafish Larvae.

Shi Q, Yang H, Chen Y, Zheng N, Li X, Wang X Int J Mol Sci. 2023; 24(13).

PMID: 37446277 PMC: 10342510. DOI: 10.3390/ijms241311099.

Long-Term Effects of Ionizing Radiation on the Hippocampus: Linking Effects of the Sonic Hedgehog Pathway Activation with Radiation Response.

Antonelli F, Casciati A, Belles M, Serra N, Linares-Vidal M, Marino C Int J Mol Sci. 2021; 22(22).

PMID: 34830484 PMC: 8624704. DOI: 10.3390/ijms222212605.

Examination of cortically projecting cholinergic neurons following exercise and environmental intervention in a rodent model of fetal alcohol spectrum disorders.

Milbocker K, Klintsova A Birth Defects Res. 2020; 113(3):299-313.

PMID: 33174398 PMC: 8274426. DOI: 10.1002/bdr2.1839.

Influence of developmental nicotine exposure on glutamatergic neurotransmission in rhythmically active hypoglossal motoneurons.

Cholanian M, Powell G, Levine R, Fregosi R Exp Neurol. 2016; 287(Pt 2):254-260.

PMID: 27477858 PMC: 5120997. DOI: 10.1016/j.expneurol.2016.07.023.

References

Shacka J, Robinson S . Exposure to prenatal nicotine transiently increases neuronal nicotinic receptor subunit alpha7, alpha4 and beta2 messenger RNAs in the postnatal rat brain. Neuroscience. 1998; 84(4):1151-61. DOI: 10.1016/s0306-4522(97)00564-2. View

Eriksson P, Fredriksson A . Developmental neurotoxicity of four ortho-substituted polychlorinated biphenyls in the neonatal mouse. Environ Toxicol Pharmacol. 2011; 1(3):155-65. DOI: 10.1016/1382-6689(96)00015-4. View

Sjodin A, Hagmar L, Jakobsson E, Bergman A . Flame retardant exposure: polybrominated diphenyl ethers in blood from Swedish workers. Environ Health Perspect. 1999; 107(8):643-8. PMC: 1566483. DOI: 10.1289/ehp.107-1566483. View

Eriksson P, Fredriksson A . Neonatal exposure to 2,2',5,5'-tetrachlorobiphenyl causes increased susceptibility in the cholinergic transmitter system at adult age. Environ Toxicol Pharmacol. 2011; 1(3):217-20. DOI: 10.1016/1382-6689(95)00017-8. View

Nordberg A, Bergh C . Effect of nicotine on passive avoidance behaviour and motoric activity in mice. Acta Pharmacol Toxicol (Copenh). 1985; 56(4):337-41. DOI: 10.1111/j.1600-0773.1985.tb01300.x. View

Ahlbom J, Fredriksson A, Eriksson P . Neonatal exposure to a type-I pyrethroid (bioallethrin) induces dose-response changes in brain muscarinic receptors and behaviour in neonatal and adult mice. Brain Res. 1994; 645(1-2):318-24. DOI: 10.1016/0006-8993(94)91666-7. View

Messing R, Vasquez B, Spiehler V, Martinez Jr J, Jensen R, Rigter H . 3H-Dihydromorphine binding in brain regions of young and aged rats. Life Sci. 1980; 26(12):921-7. DOI: 10.1016/0024-3205(80)90112-5. View

Fein G, Jacobson J, Jacobson S, Schwartz P, Dowler J . Prenatal exposure to polychlorinated biphenyls: effects on birth size and gestational age. J Pediatr. 1984; 105(2):315-20. DOI: 10.1016/s0022-3476(84)80139-0. View

Jacobson J, Jacobson S . Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med. 1996; 335(11):783-9. DOI: 10.1056/NEJM199609123351104. View

10.

Tilson H, Jacobson J, Rogan W . Polychlorinated biphenyls and the developing nervous system: cross-species comparisons. Neurotoxicol Teratol. 1990; 12(3):239-48. DOI: 10.1016/0892-0362(90)90095-t. View

11.

Kuhar M, Birdsall N, BURGEN A, Hulme E . Ontogeny of muscarinic receptors in rat brain. Brain Res. 1980; 184(2):375-83. DOI: 10.1016/0006-8993(80)90806-9. View

12.

Drachman D . Memory and cognitive function in man: does the cholinergic system have a specific role?. Neurology. 1977; 27(8):783-90. DOI: 10.1212/wnl.27.8.783. View

13.

Balfour D . Influence of nicotine on the release of monoamines in the brain. Prog Brain Res. 1989; 79:165-72. DOI: 10.1016/s0079-6123(08)62476-0. View

14.

Beani L, Bianchi C, Ferraro L, Nilsson L, Nordberg A, Romanelli L . Effect of nicotine on the release of acetylcholine and amino acids in the brain. Prog Brain Res. 1989; 79:149-55. DOI: 10.1016/s0079-6123(08)62474-7. View

15.

Rogan W, Gladen B, Hung K, Koong S, Shih L, Taylor J . Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science. 1988; 241(4863):334-6. DOI: 10.1126/science.3133768. View

16.

Henningfield J, Woodson P . Dose-related actions of nicotine on behavior and physiology: review and implications for replacement therapy for nicotine dependence. J Subst Abuse. 1989; 1(3):301-17. View

17.

Miner L, Collins A . Strain comparison of nicotine-induced seizure sensitivity and nicotinic receptors. Pharmacol Biochem Behav. 1989; 33(2):469-75. DOI: 10.1016/0091-3057(89)90532-7. View

18.

Narang N . In situ determination of M1 and M2 muscarinic receptor binding sites and mRNAs in young and old rat brains. Mech Ageing Dev. 1995; 78(3):221-39. DOI: 10.1016/0047-6374(94)01539-x. View

19.

Seegal R . Epidemiological and laboratory evidence of PCB-induced neurotoxicity. Crit Rev Toxicol. 1996; 26(6):709-37. DOI: 10.3109/10408449609037481. View

20.

Campbell B, Lytle L, Fibiger H . Ontogeny of adrenergic arousal and cholinergic inhibitory mechanisms in the rat. Science. 1969; 166(3905):635-7. DOI: 10.1126/science.166.3905.635. View