» Articles » PMID: 15109945

Ligand Efficiency: a Useful Metric for Lead Selection

Overview
Specialty Pharmacology
Date 2004 Apr 28
PMID 15109945
Citations 456
Authors
Affiliations
Soon will be listed here.
Citing Articles

Leveraging efficiency metrics for the optimization of CELMoDs™ as cereblon-based molecular glue degraders.

Jia L, Riggs J, Weiss D, Claus B, Shanmugasundaram V, Johnson S RSC Med Chem. 2025; .

PMID: 40047000 PMC: 11876855. DOI: 10.1039/d4md00870g.


Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.

Sharp S, Martella M, DAgostino S, Milton C, Ward G, Woodhead A Nat Commun. 2025; 15(1):10037.

PMID: 40016190 PMC: 11868579. DOI: 10.1038/s41467-024-54356-1.


Fragment Screening Identifies Novel Allosteric Binders and Binding Sites in the VHR () Phosphatase.

Wu J, Baranowski M, Aleshin A, Isiorho E, Lambert L, De Backer L ACS Omega. 2025; 10(5):4912-4926.

PMID: 39959108 PMC: 11822521. DOI: 10.1021/acsomega.4c10321.


Identification of Structurally Novel KRAS Inhibitors through Covalent DNA-Encoded Library Screening.

Huang D, Manoni F, Sun Z, Liu R, Allen J, Banerjee A J Med Chem. 2025; 68(4):4801-4817.

PMID: 39930787 PMC: 11873997. DOI: 10.1021/acs.jmedchem.4c03071.


Probing the Histamine H Receptor Binding Site to Explore Ligand Binding Kinetics.

Kuhne S, Bosma R, Kooistra A, Riemens R, Stroet M, Vischer H J Med Chem. 2024; 68(1):448-464.

PMID: 39723903 PMC: 11726634. DOI: 10.1021/acs.jmedchem.4c02043.