Imaging of Malignant Tumours of the Long Bones in Children: Monitoring Response to Neoadjuvant Chemotherapy and Preoperative Assessment

Overview

Journal Pediatr Radiol

Specialty Pediatrics

Date 2004 Apr 23

PMID 15103428

Citations 34

Authors

Herve Brisse

Liliane Ollivier

Veronique Edeline

Helene Pacquement

Jean Michon

Christophe Glorion

Sylvia Neuenschwander

Affiliations

Soon will be listed here.

Abstract

This review focuses on imaging of osteosarcoma and Ewing's sarcoma of the long bones in children during preoperative neoadjuvant chemotherapy. Morphological criteria on plain films and conventional static MRI are insufficiently correlated with histological response. We review the contribution of dynamic MRI, diffusion-weighted MR and nuclear medicine (18FDG-PET) to monitor tumoural necrosis. MRI is currently the best method to evaluate local extension prior to tumour resection, especially to assess the feasibility of conservative surgery. Quantitative models in dynamic MRI and 18FDG-PET are currently being developed in order to find new early prognostic criteria, but for the time being, treatment protocols are still based on the gold standard of histological response.

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