Monoamine Related Functional Gene Variants and Relationships to Monoamine Metabolite Concentrations in CSF of Healthy Volunteers

Overview

Journal BMC Psychiatry

Publisher Biomed Central

Specialty Psychiatry

Date 2004 Apr 23

PMID 15102340

Citations 14

Authors

Erik G Jonsson

Jessica Bah

Jonas Melke

Rami Abou Jamra

Johannes Schumacher

Lars Westberg

Roland Ivo

Sven Cichon

Peter Propping

Markus M Nothen

Elias Eriksson

Goran C Sedvall

Affiliations

Soon will be listed here.

Abstract

Background: Concentrations of monoamine metabolites in human cerebrospinal fluid (CSF) have been used extensively as indirect estimates of monoamine turnover in the brain. CSF monoamine metabolite concentrations are partly determined by genetic influences.

Methods: We investigated possible relationships between DNA polymorphisms in the serotonin 2C receptor (HTR2C), the serotonin 3A receptor (HTR3A), the dopamine D4 receptor (DRD4), and the dopamine beta-hydroxylase (DBH) genes and CSF concentrations of 5-hydroxyindolacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy volunteers (n = 90).

Results: The HTR3A 178 C/T variant was associated with 5-HIAA levels (p = 0.02). The DBH-1021 heterozygote genotype was associated with 5-HIAA (p = 0.0005) and HVA (p = 0.009) concentrations. Neither the HTR2C Cys23Ser variant, nor the DRD4 -521 C/T variant were significantly associated with any of the monoamine metabolites.

Conclusions: The present results suggest that the HTR3A and DBH genes may participate in the regulation of dopamine and serotonin turnover rates in the central nervous system.

Citing Articles

Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis.

Andreou D, Soderman E, Axelsson T, Sedvall G, Terenius L, Agartz I Behav Brain Funct. 2014; 10:26.

PMID: 25073638 PMC: 4123495. DOI: 10.1186/1744-9081-10-26.

DBH gene as predictor of response in a cocaine vaccine clinical trial.

Kosten T, Domingo C, Hamon S, Nielsen D Neurosci Lett. 2013; 541:29-33.

PMID: 23458673 PMC: 3631430. DOI: 10.1016/j.neulet.2013.02.037.

Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.

Luykx J, Bakker S, Lentjes E, Neeleman M, Strengman E, Mentink L Mol Psychiatry. 2013; 19(2):228-34.

PMID: 23319000 DOI: 10.1038/mp.2012.183.

Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse.

Herman A, Balogh K Subst Abuse Rehabil. 2012; 3(1):49-57.

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Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine β-hydroxylase.

Kosten T, Wu G, Huang W, Harding M, Hamon S, Lappalainen J Biol Psychiatry. 2012; 73(3):219-24.

PMID: 22906516 PMC: 3514624. DOI: 10.1016/j.biopsych.2012.07.011.

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