Characterisation and Pharmacological Sensitivity of Antigen Arthritis Induced by Methylated Bovine Serum Albumin in the Rat

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1992 Jan 1

PMID 1509982

Citations 16

Authors

R J Griffiths

Affiliations

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Abstract

The optimum conditions for the induction of antigen-induced arthritis in the rat have been studied. Two immunisations with methylated bovine serum albumin (mBSA) (0.5 mg) in Freund's complete adjuvant (FCA) containing 0.375 mg Mycobacterium tuberculosis followed by an intra-articular injection of mBSA (0.5 mg) led to the production of a chronic, erosive arthritis. The development of the arthritis was associated with the appearance of T lymphocytes and other inflammatory cells in the synovium. Male and female animals were equally susceptible to the disease. Prednisolone, indomethacin and methotrexate inhibited the development of the arthritis but ibuprofen and D-penicillamine were without any significant effect.

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References

Blackham A, Farmer J, Radziwonik H, Westwick J . The role of prostaglandins in rabbit monoarticular arthritis. Br J Pharmacol. 1974; 51(1):35-44. PMC: 1776840. DOI: 10.1111/j.1476-5381.1974.tb09629.x. View

van den Berg W, van de Putte L, Zwarts W, Joosten L . Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice. J Clin Invest. 1984; 74(5):1850-9. PMC: 425365. DOI: 10.1172/JCI111604. View

Wilder R, Calandra G, Garvin A, Wright K, Hansen C . Strain and sex variation in the susceptibility to streptococcal cell wall-induced polyarthritis in the rat. Arthritis Rheum. 1982; 25(9):1064-72. DOI: 10.1002/art.1780250906. View

Dumonde D, GLYNN L . The production of arthritis in rabbits by an immunological reaction to fibrin. Br J Exp Pathol. 1962; 43:373-83. PMC: 2094309. View

Fox A, GLYNN L . Persistence of antigen in nonarthritic joints. Ann Rheum Dis. 1975; 34(5):431-7. PMC: 1006444. DOI: 10.1136/ard.34.5.431. View

Hunneyball I, Crossley M, Spowage M . Pharmacological studies of antigen-induced arthritis in BALB/c mice. I. Characterization of the arthritis and the effects of steroidal and non-steroidal anti-inflammatory agents. Agents Actions. 1986; 18(3-4):384-93. DOI: 10.1007/BF01965002. View

Jacobs C, Young D, Tyler S, Callis G, Gillis S, Conlon P . In vivo treatment with IL-1 reduces the severity and duration of antigen-induced arthritis in rats. J Immunol. 1988; 141(9):2967-74. View

Billingham M . Models of arthritis and the search for anti-arthritic drugs. Pharmacol Ther. 1983; 21(3):389-428. DOI: 10.1016/0163-7258(83)90062-1. View

Dijkstra C, Dopp E, Vogels I, Van Noorden C . Macrophages and dendritic cells in antigen-induced arthritis. An immunohistochemical study using cryostat sections of the whole knee joint of rat. Scand J Immunol. 1987; 26(5):513-23. DOI: 10.1111/j.1365-3083.1987.tb02285.x. View

10.

Brackertz D, Mitchell G, Vadas M, Mackay I, Miller J . Studies on antigen-induced arthritis in mice. II. Immunologic correlates of arthritis susceptibility in mice. J Immunol. 1977; 118(5):1639-44. View

11.

Van Noorden C, Smith R, Rasnick D . Cysteine proteinase activity in arthritic rat knee joints and the effects of a selective systemic inhibitor, Z-Phe-AlaCH2F. J Rheumatol. 1988; 15(10):1525-35. View

12.

Hunneyball I, Crossley M, Spowage M . Pharmacological studies of antigen-induced arthritis in BALB/c mice. II. The effects of second-line antirheumatic drugs and cytotoxic agents on the histopathological changes. Agents Actions. 1986; 18(3-4):394-400. DOI: 10.1007/BF01965003. View

13.

Brackertz D, Mitchell G, Mackay I . Antigen-induced arthritis in mice. I. Induction of arthritis in various strains of mice. Arthritis Rheum. 1977; 20(3):841-50. DOI: 10.1002/art.1780200314. View

14.

Brackertz D, Mitchell G, Vadas M, Mackay I . Studies on antigen-induced arthritis in mice. III. Cell and serum transfer experiments. J Immunol. 1977; 118(5):1645-8. View

15.

Klasen I, Donselaar I, Ladestein R, van den Berg W, Benner R . Joint inflammations and flare-up reactions in mice induced by a helper T cell clone. Agents Actions. 1986; 19(5-6):331-4. DOI: 10.1007/BF01971242. View