» Articles » PMID: 15049520

An Update on the Pathogenesis and Epidemiology of Osteoarthritis

Overview
Specialty Radiology
Date 2004 Mar 31
PMID 15049520
Citations 162
Authors
Affiliations
Soon will be listed here.
Abstract

Osteoarthritis is a disease affecting all joint structures, not just hyaline articular cartilage. It develops as a consequence of injurious activities acting on a vulnerable joint. The correlation between structural changes of the disease and joint symptoms is poor. Risk factors include age, obesity, and joint injury. Risk factors for symptoms include bone marrow edema, synovitis, and joint effusion.

Citing Articles

Physical health in young males and risk of chronic musculoskeletal, cardiovascular, and respiratory diseases by middle age: A population-based cohort study.

Turkiewicz A, Magnusson K, Timpka S, Kiadaliri A, DellIsola A, Dell-Isola A PLoS Med. 2025; 22(1):e1004517.

PMID: 39836663 PMC: 11793790. DOI: 10.1371/journal.pmed.1004517.


A standardized extract shows improvements in knee osteoarthritis within five days-a double-blind, randomized, three-arm, parallel-group, multi-center, placebo-controlled trial.

Majeed A, Majeed S, Satish G, Manjunatha R, Rabbani S, Patil N Front Pharmacol. 2024; 15:1428440.

PMID: 39092235 PMC: 11291344. DOI: 10.3389/fphar.2024.1428440.


FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation.

Yuan Z, Yang L, Li Y, Li X, Peng C, Pan J BMC Musculoskelet Disord. 2024; 25(1):282.

PMID: 38609896 PMC: 11010333. DOI: 10.1186/s12891-024-07411-3.


Prevalence of Neuropathic Pain in Patients with Osteoarthritis.

Zuluaga M, Urbano I, Tovar-Sanchez M, Baena C, Pacichana-Quinayaz S, Bonilla-Escobar F Rev Bras Ortop (Sao Paulo). 2023; 58(6):e924-e931.

PMID: 38077759 PMC: 10708978. DOI: 10.1055/s-0043-1776986.


Arthritis Foundation/HSS Workshop on Hip Osteoarthritis, Part 1: Epidemiology, Early Development, and Cohorts From Around the World.

Kim J, Agricola R, Kim Y, Lane N, Millis M, Nelson A HSS J. 2023; 19(4):395-401.

PMID: 37937080 PMC: 10626936. DOI: 10.1177/15563316231189748.