Structures of the Lectins from Pseudomonas Aeruginosa: Insight into the Molecular Basis for Host Glycan Recognition

Overview

Journal Microbes Infect

Publisher Elsevier

Specialties Allergy & Immunology
Microbiology

Date 2004 Mar 31

PMID 15049333

Citations 82

Authors

Anne Imberty

Michaela Wimmerova

Edward P Mitchell

Nechama Gilboa-Garber

Affiliations

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Abstract

The opportunistic human pathogen Psuedomonas aeruginosa produces two lectins in close association with virulence factors: PA-IL adn PA-IIL, which bind to galactose- and fucose/mannose-containing glycoconjugates, respectively. We review here the structural aspects of these lectins relative to their putative roles in host recognition, cell surface adhesion and biofilm formation.

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