Molecular Genetics of Alzheimer's Disease

Overview

Journal Curr Psychiatry Rep

Publisher Current Science

Specialty Psychiatry

Date 2004 Mar 25

PMID 15038915

Citations 19

Authors

Pau Pastor

Alison M Goate

Affiliations

Soon will be listed here.

Abstract

Alzheimer disease (AD) is the most common cause of dementia. In the past decade, many advances in the understanding of the etiology of AD have been reported. Familial early onset AD is a heterogeneous disorder that can be caused by mutations in at least three different genes. Current studies are focused on identifying genetic risk factors for late onset AD. In this article, the authors will review the progress in understanding the pathogenic implications of the genes mutated in familial early onset AD and the mapping studies to identify additional genes involved in late-onset AD.

Citing Articles

Cross-View Neuroimage Pattern Analysis in Alzheimer's Disease Staging.

Liu S, Cai W, Pujol S, Kikinis R, Feng D Front Aging Neurosci. 2016; 8:23.

PMID: 26941639 PMC: 4763344. DOI: 10.3389/fnagi.2016.00023.

Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease.

Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton M, Troakes C Neurobiol Aging. 2014; 35(10):2422.e13-6.

PMID: 24880964 PMC: 4099516. DOI: 10.1016/j.neurobiolaging.2014.04.026.

Association of CALHM1 Gene Polymorphism with Late Onset Alzheimer's Disease in Iranian Population.

Aqdam M, Kamali K, Rahgozar M, Ohadi M, Manoochehri M, Tahami A Avicenna J Med Biotechnol. 2013; 2(3):153-7.

PMID: 23408664 PMC: 3558160.

Ultrastructural studies in APP/PS1 mice expressing human ApoE isoforms: implications for Alzheimer's disease.

Dikranian K, Kim J, Stewart F, Levy M, Holtzman D Int J Clin Exp Pathol. 2012; 5(6):482-95.

PMID: 22949930 PMC: 3430100.

Molecular brain imaging in the multimodality era.

Price J J Cereb Blood Flow Metab. 2012; 32(7):1377-92.

PMID: 22434068 PMC: 3390805. DOI: 10.1038/jcbfm.2012.29.

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