Uterine Rupture Associated with Misoprostol Labor Induction in Women with Previous Cesarean Delivery

Overview

Journal Eur J Obstet Gynecol Reprod Biol

Specialties Gynecology & Obstetrics
Reproductive Medicine

Date 2004 Mar 24

PMID 15036710

Citations 16

Authors

Halil Aslan

Emine Unlu

Mehmet Agar

Yavuz Ceylan

Affiliations

Soon will be listed here.

Abstract

Objective: To review our experience with uterine rupture in patients undergoing a trial of labor with a history of previous cesarean delivery in which labor was induced with misoprostol.

Study Design: A retrospective chart review was used to select patients who underwent induction of labor with misoprostol during the period from February 1999 to June 2002. Women with a history of cesarean delivery were retrospectively compared with those without uterine scarring.

Results: Uterine rupture occurred in 4 of 41 patients with previous cesarean delivery who had labor induced with misoprostol. The rate of uterine rupture (9.7%) was significantly higher in patients with a previous cesarean delivery (P<0.001). No uterine rupture occurred in 50 patients without uterine scarring. Women with a history of cesarean delivery were more likely to have oxytocin augmentation than those without uterine scarring (41% versus 20%; P=0.037).

Conclusion: Misoprostol induction of labor increases the risk of uterine rupture in women with a history of cesarean delivery.

Citing Articles

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Yang L, Xu W Sci Rep. 2025; 15(1):2452.

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Short stature and vaginal dinoprostone as independent predictors of composite maternal-newborn adverse outcomes in induction of labor after one previous cesarean: a retrospective cohort study.

Tan S, Bashirudin S, Rajaratnam R, Gan F BMC Pregnancy Childbirth. 2024; 24(1):455.

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A cesarean section scar dehiscence during the first trimester of an intrauterine pregnancy: a rare case report and literature review.

Alhalak F, Haddad S, Nasseh G, Nasseh M, Marroush J, Abaza R J Surg Case Rep. 2024; 2024(6):rjae422.

PMID: 38912433 PMC: 11190852. DOI: 10.1093/jscr/rjae422.

Misoprostol use in obstetrics.

Rev Bras Ginecol Obstet. 2023; 45(6):356-368.

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A Comparative Study of the Efficacy and Safety of Oral Misoprostol, Intravenous Oxytocin, and Intravaginal Dinoprostone for Labor Induction in Pakistani Women.

Wasim A, Khan M, Aneela F, Khan H, Solis M, Shabir I Cureus. 2023; 15(5):e39768.

PMID: 37398821 PMC: 10312116. DOI: 10.7759/cureus.39768.