Spinal Fusion Using an Autologous Growth Factor Gel and a Porous Resorbable Ceramic

Overview

Journal Eur Spine J

Specialty Orthopedics

Date 2004 Mar 23

PMID 15034772

Citations 6

Authors

William R Walsh

Andreas Loefler

Sean Nicklin

Doug Arm

Ralph E Stanford

Yan Yu

Richard Harris

R M Gillies

Affiliations

Soon will be listed here.

Abstract

Augmenting healing through a single application of an exogenous growth factor or bone morphogenetic protein is not a new concept. The use of autologous growth factors through platelet isolation and concentration provides multiple endogenous growth factors to the healing site. A posterolateral fusion model in aged sheep (5- to 6-year-old ewes) was used to examine the effects of the addition of growth factors through autologous platelet isolation on the biomechanic and histologic properties of the fusion using a resorbable coral bone graft substitute. At 6 months the combination of autologous growth factors to the Pro Osteon 500R plus aspirated bone marrow resulted in the greatest bending stiffness but not ultimate load. Autologous growth factors can be isolated from platelets and concentrated to provide multiple growth factors to the fusion site to aid in spinal fusion.

Citing Articles

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van Dijk L, Barrere-de Groot F, Rosenberg A, Pelletier M, Christou C, de Bruijn J Clin Spine Surg. 2020; 33(6):E276-E287.

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Biphasic calcium phosphate with submicron surface topography in an model of instrumented posterolateral spinal fusion.

van Dijk L, Duan R, Luo X, Barbieri D, Pelletier M, Christou C JOR Spine. 2019; 1(4):e1039.

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Fabrication of porous calcite using chopped nylon fiber and its evaluation using rats.

Ishikawa K, Tram N, Tsuru K, Toita R J Mater Sci Mater Med. 2015; 26(2):94.

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Osteogenic potentials of osteophytes in the cervical spine compared with patient matched bone marrow stromal cells.

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