[Photodynamic Therapy of Cutaneous Leishmaniasis. A Promising New Therapeutic Modality]

Overview

Journal Hautarzt

Specialty Dermatology

Date 2004 Mar 17

PMID 15021933

Citations 2

Authors

K Gardlo

S Hanneken

T Ruzicka

N J Neumann

Affiliations

Soon will be listed here.

Abstract

We report about a 19-year-old Turkish patient who presented with cutaneous leishmaniasis after a holiday in Turkey. Cutaneous leishmaniasis often heals spontaneously leading to life-long immunity, but it can persist and lead to extensive scarring. In the literature, many therapeutic modalities have been reported; however, they can be accompanied by severe side effects. In our patient, photodynamic therapy resulted in healing of the lesion with only slight hypopigmentation.

Citing Articles

Monitoring the efficacy of antimicrobial photodynamic therapy in a murine model of cutaneous leishmaniasis using L. major expressing GFP.

Latorre-Esteves E, Akilov O, Rai P, Beverley S, Hasan T J Biophotonics. 2010; 3(5-6):328-35.

PMID: 20376860 PMC: 2876225. DOI: 10.1002/jbio.201000008.

[The leishmaniasis - a parasitel infection as differential diagnosis of malignant tumours of oral mucosa. A case report and review of literature].

Wysluch A, Sommerer F, Ramadan H, Loeffelbein D, Wolff K, Holzle F Mund Kiefer Gesichtschir. 2007; 11(3):167-73.

PMID: 17566798 DOI: 10.1007/s10006-007-0061-9.

References

Navin T, Arana B, Arana F, Berman J, Chajon J . Placebo-controlled clinical trial of sodium stibogluconate (Pentostam) versus ketoconazole for treating cutaneous leishmaniasis in Guatemala. J Infect Dis. 1992; 165(3):528-34. DOI: 10.1093/infdis/165.3.528. View

Gardlo K, Horska Z, Enk C, Rauch L, Megahed M, Ruzicka T . Treatment of cutaneous leishmaniasis by photodynamic therapy. J Am Acad Dermatol. 2003; 48(6):893-6. DOI: 10.1067/mjd.2003.218. View

Herwaldt B . Leishmaniasis. Lancet. 1999; 354(9185):1191-9. DOI: 10.1016/S0140-6736(98)10178-2. View

Bahamdan K, Tallab T, Johargi H, Nourad M, Ibrahim K, el Sherbini A . Terbinafine in the treatment of cutaneous leishmaniasis: a pilot study. Int J Dermatol. 1997; 36(1):59-60. DOI: 10.1046/j.1365-4362.1997.00021.x. View

Saldanha A, Romero G, Merchan-Hamann E, Magalhaes A, Macedo V . [A comparative study between sodium stibogluconate BP 88R and meglumine antimoniate in the treatment of cutaneous leishmaniasis. I. The efficacy and safety]. Rev Soc Bras Med Trop. 1999; 32(4):383-7. DOI: 10.1590/s0037-86821999000400008. View

Kubba R, Al-Gindan Y, El-Hassan A, Omer A . Clinical diagnosis of cutaneous leishmaniasis (oriental sore). J Am Acad Dermatol. 1987; 16(6):1183-9. DOI: 10.1016/s0190-9622(87)70155-8. View

Enk C, Fritsch C, Jonas F, Nasereddin A, Ingber A, Jaffe C . Treatment of cutaneous leishmaniasis with photodynamic therapy. Arch Dermatol. 2003; 139(4):432-4. DOI: 10.1001/archderm.139.4.432. View

Berman J . Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years. Clin Infect Dis. 1997; 24(4):684-703. DOI: 10.1093/clind/24.4.684. View

Enk C, Gardlo K, Hochberg M, Ingber A, Ruzicka T . [Cutaneous leishmaniasis]. Hautarzt. 2003; 54(6):506-12. DOI: 10.1007/s00105-003-0530-5. View

10.

Herwaldt B, Berman J . Recommendations for treating leishmaniasis with sodium stibogluconate (Pentostam) and review of pertinent clinical studies. Am J Trop Med Hyg. 1992; 46(3):296-306. DOI: 10.4269/ajtmh.1992.46.296. View

11.

Levine N . Cutaneous leishmaniasis treated with controlled localized heating. Arch Dermatol. 1992; 128(6):759-61. View

12.

Stojiljkovic I, Evavold B, Kumar V . Antimicrobial properties of porphyrins. Expert Opin Investig Drugs. 2001; 10(2):309-20. DOI: 10.1517/13543784.10.2.309. View

13.

Faris R, Jarallah J, Khoja T, Al-Yamani M . Intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate antimony. Int J Dermatol. 1993; 32(8):610-2. DOI: 10.1111/j.1365-4362.1993.tb05044.x. View

14.

Moskowitz P, Kurban A . Treatment of cutaneous leishmaniasis: retrospectives and advances for the 21st century. Clin Dermatol. 1999; 17(3):305-15. DOI: 10.1016/s0738-081x(99)00049-8. View

15.

Davidson R . Practical guide for the treatment of leishmaniasis. Drugs. 1999; 56(6):1009-18. DOI: 10.2165/00003495-199856060-00005. View

16.

Dogra J, Aneja N, Lal B, Mishra S . Cutaneous leishmaniasis in India. Clinical experience with itraconazole (R51 211 Janssen). Int J Dermatol. 1990; 29(9):661-2. DOI: 10.1111/j.1365-4362.1990.tb02593.x. View

17.

Abok K, Cadenas E, BRUNK U . An experimental model system for leishmaniasis. Effects of porphyrin-compounds and menadione on Leishmania parasites engulfed by cultured macrophages. APMIS. 1988; 96(6):543-51. View

18.

Bassiouny A, El Meshad M, Talaat M, Kutty K, Metawaa B . Cryosurgery in cutaneous leishmaniasis. Br J Dermatol. 1982; 107(4):467-74. DOI: 10.1111/j.1365-2133.1982.tb00390.x. View

19.

Grevelink S, Lerner E . Leishmaniasis. J Am Acad Dermatol. 1996; 34(2 Pt 1):257-72. DOI: 10.1016/s0190-9622(96)80121-6. View