Multiple Roles for ISWI in Transcription, Chromosome Organization and DNA Replication

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2004 Mar 17

PMID 15020052

Citations 92

Authors

Davide F V Corona

John W Tamkun

Affiliations

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Abstract

ISWI functions as the ATPase subunit of multiple chromatin-remodeling complexes. These complexes use the energy of ATP hydrolysis to slide nucleosomes and increase chromatin fluidity, thereby modulating the access of transcription factors and other regulatory proteins to DNA. Here we discuss recent progress toward understanding the biological functions of ISWI, with an emphasis on its roles in transcription, chromosome organization and DNA replication.

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