Risk Factors for Central Serous Chorioretinopathy: a Case-control Study

Overview

Journal Ophthalmology

Publisher Elsevier

Specialty Ophthalmology

Date 2004 Mar 17

PMID 15019370

Citations 161

Authors

Robert Haimovici

Sean Koh

David R Gagnon

Todd Lehrfeld

Sarah Wellik

Affiliations

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Abstract

Purpose: To identify systemic factors associated with the development of central serous chorioretinopathy (CSCR).

Design: Retrospective, case-control study.

Participants And Controls: 312 cases and 312 controls.

Results: By use of a multivariate analysis, the previously described risk factors, systemic steroid use (odds ratio [OR], 37.1; 95% confidence interval [CI], 6.2-221.8), and pregnancy (OR, 7.1; 95% CI, 1.0-50.7), were strongly associated with CSCR. Additional risk factors identified by this study include antibiotic use (OR, 6.2; 95% CI, 1.0-37.9), alcohol use (OR, 4.9; 95% CI, 1.5-16.3), untreated hypertension (OR, 3.3; 95% CI, 1.3-8.5), and allergic respiratory disease (OR, 2.5; 95% CI, 1.2-5.1).

Conclusions: A wide variety of systemic factors are associated with CSCR. Prospective studies are warranted to evaluate the nature and significance of these associations further.

Citing Articles

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Samanta A, Driban M, Sahoo N, Parameswarappa D, Singh S, Caplash S J Clin Med. 2025; 14(3).

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[Stress and other risk factors in central serous chorioretinopathy-A myth?].

Hufnagel H, Lahmann C, Pauleikhoff L, Lange C Ophthalmologie. 2025; 122(3):162-169.

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Quantifying choroidal and retinal thicknesses variations via optical coherence tomography in different stages of pediatric keratoconus.

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Sparling K, Butler D Drugs Aging. 2024; 41(10):795-808.

PMID: 39285122 DOI: 10.1007/s40266-024-01143-8.

Increased oxidative stress biomarkers in central serous chorioretinopathy.

Ercin Akidan E, Yilmaz E, Yilmaz N, Akidan M Sci Rep. 2024; 14(1):21099.

PMID: 39256410 PMC: 11387491. DOI: 10.1038/s41598-024-71890-6.