Microcystic Tubulopapillary Carcinoma of the Pancreas: a New Tumor Entity?

Overview

Journal Virchows Arch

Specialties Cell Biology
Molecular Biology
Pathology

Date 2004 Mar 12

PMID 15014986

Citations 10

Authors

Irene Esposito

Andrea Bauer

Jorg D Hoheisel

Jorg Kleeff

Helmut Friess

Frank Bergmann

Ralf J Rieker

Herwart F Otto

Gunter Kloppel

Roland Penzel

Affiliations

Soon will be listed here.

Abstract

An unusual pancreatic tumor with microcystic and tubulopapillary features was observed in a 53-year-old woman. The tumor presented as a large, focally cystic mass in the head of the pancreas, which compressed the surrounding structures. The histological and immunohistochemical analysis revealed a neoplasm that could not be assigned to any of the known pancreatic tumor types. At the molecular level, the tumor showed inactivation of the DPC4/SMAD4 gene, deletion of exon 1 of the p16(INK4A) gene and a point mutation at codon 34 (GGA>AGA) of beta-catenin. Transcriptional profiling analyses and subsequent correspondence cluster analysis demonstrated that the transcriptional profile of the tumor differed distinctly from that of ductal adenocarcinomas, pancreatic cystic tumors and normal pancreatic tissues. These data suggest that the neoplasm most likely represents a new pancreatic tumor entity, which we would like to refer to as microcystic tubulopapillary tumor.

Citing Articles

Intraductal tubulopapillary neoplasm (ITPN) of the pancreas: a distinct entity among pancreatic tumors.

Paolino G, Esposito I, Hong S, Basturk O, Mattiolo P, Kaneko T Histopathology. 2022; 81(3):297-309.

PMID: 35583805 PMC: 9544156. DOI: 10.1111/his.14698.

[Intraductal neoplasms of the pancreas].

Esposito I, Haberle L, Yavas A, Kraft A, Gaida M Pathologe. 2021; 42(5):472-483.

PMID: 34402978 DOI: 10.1007/s00292-021-00966-1.

Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma.

Basturk O, Berger M, Yamaguchi H, Adsay V, Askan G, Bhanot U Mod Pathol. 2017; 30(12):1760-1772.

PMID: 28776573 DOI: 10.1038/modpathol.2017.60.

Intraductal Tubulopapillary Neoplasm of the Pancreas: A Clinicopathologic and Immunohistochemical Analysis of 33 Cases.

Basturk O, Adsay V, Askan G, Dhall D, Zamboni G, Shimizu M Am J Surg Pathol. 2016; 41(3):313-325.

PMID: 27984235 PMC: 5309137. DOI: 10.1097/PAS.0000000000000782.

Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases.

Schlitter A, Jang K, Kloppel G, Saka B, Hong S, Choi H Mod Pathol. 2015; 28(9):1249-64.

PMID: 26111977 DOI: 10.1038/modpathol.2015.61.

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