The Ins and Outs of FoxO Shuttling: Mechanisms of FoxO Translocation and Transcriptional Regulation

Overview

Journal Biochem J

Specialty Biochemistry

Date 2004 Mar 10

PMID 15005655

Citations 311

Authors

Lars P van der Heide

Marco F M Hoekman

Marten P Smidt

Affiliations

Soon will be listed here.

Abstract

FoxO (forkhead box O; forkhead members of the O class) are transcription factors that function under the control of insulin/insulin-like signalling. FoxO factors have been associated with a multitude of biological processes, including cell-cycle, cell death, DNA repair, metabolism and protection from oxidative stress. Central to the regulation of FoxO factors is a shuttling system, which confines FoxO factors to either the nucleus or the cytosol. Shuttling of FoxO requires protein phosphorylation within several domains, and association with 14-3-3 proteins and the nuclear transport machinery. Description of the FoxO-shuttling mechanism contributes to the understanding of FoxO function in relation to signalling and gene regulation.

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