Human Monoclonal Antibody Fragment Specific for Glycoprotein G in Herpes Simplex Virus Type 2 with Applications for Serotype-specific Diagnosis

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2004 Mar 9

PMID 15004085

Citations 4

Authors

Francesca Bugli

Stefania Manzara

Riccardo Torelli

Rosalia Graffeo

Rosaria Santangelo

Paola Cattani

Giovanni Fadda

Affiliations

Soon will be listed here.

Abstract

A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.

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