Comparison of Extracellular Phospholipase Activities in Clinical and Environmental Aspergillus Fumigatus Isolates

Overview

Journal Med Mycol

Publisher Oxford University Press

Specialties Microbiology
Veterinary Medicine

Date 2004 Feb 26

PMID 14982117

Citations 9

Authors

Mike Birch

David W Denning

Geoffrey D Robson

Affiliations

Soon will be listed here.

Abstract

Extracellular phospholipase production by environmental and clinical isolates of Aspergillus fumigatus collected from several centres world-wide were compared. All isolates produced extracellular phospholipases which included phospholipase C and a phospholipid acyl hydrolase (phospholipase A and/or phospholipase B) activity. Clinical isolates of A. fumigatus produced the largest zone sizes in a diffusion assay and clinical isolates produced more extracellular phospholipase C than environmental isolates. However, environmental isolates of A. fumigatus showed increased acyl hydrolase activity compared to clinical isolates of A. fumigatus. This study suggests that extracellular phospholipase C activity, but not extracellular acyl hydrolase activity may be important in the pathogenicity of A. fumigatus.

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