Kinetic Analysis of Genomewide Gene Expression Reveals Molecule Circuitries That Control T Cell Activation and Th1/2 Differentiation

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2004 Feb 24

PMID 14978277

Citations 21

Authors

Binfeng Lu

Panayiotis Zagouras

James E Fischer

Junfeng Lu

Baiyong Li

Richard A Flavell

Affiliations

Soon will be listed here.

Abstract

The global gene expression profiling of early T helper (Th) 1 and Th2 differentiation reveals that this process can be divided into two stages, activation and differentiation. The activation stage is manifested in coordinated mobilization of the replication machinery, a process that we hypothesize may be responsible for establishing genomewide opening of transcription loci. The molecular programs underlying the differentiation stage consist of highly regulated expression of functional groups of genes that are important for the biological properties of Th1/2 cells and transcription factors that are likely important in establishing terminal differentiation of these cells. The kinetics of expression pattern of a number of transcription factors shed new light on the molecular events that shape the outcome of Th1/2 differentiation.

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