Routes to Transplant Tolerance Versus Rejection; the Role of Cytokines

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2004 Feb 21

PMID 14975235

Citations 22

Authors

Patrick T Walsh

Terry B Strom

Laurence A Turka

Affiliations

Soon will be listed here.

Abstract

The alloimmune response can be divided into specific junctures where critical decisions between tolerance and immunity are made which define the outcome of the transplant. At these "decision nodes" various cytokines direct alloresponsive T cells to develop either a proinflammatory response aimed at graft destruction or an immunoregulatory response facilitating graft acceptance. This review will focus on the role of these cytokines in influencing the progression of an alloimmune response leading ultimately to either allograft survival or rejection.

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