Thrombolysis for Cerebral Vein and Dural Sinus Thrombosis

Overview

Journal Cochrane Database Syst Rev

Publisher Wiley

Specialties General Medicine
Health Services

Date 2004 Feb 20

PMID 14974030

Citations 30

Authors

A Ciccone

P Canhao

F Falcao

J M Ferro

R Sterzi

Affiliations

Soon will be listed here.

Abstract

Background: Treatment of cerebral sinus thrombosis with thrombolytics has been reported in cases with a deteriorating clinical course despite anticoagulant therapy. The rationale of this treatment is to promote rapid recanalisation of the occluded sinus.

Objectives: To review the available evidence on the efficacy and safety of thrombolysis in confirmed cerebral sinus thrombosis.

Search Strategy: We searched the Cochrane Stroke Group trials register (March 2003), the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 1, 2003), MEDLINE (1966 to March 2003), EMBASE (1980 to March 2003), and reference lists of all relevant publications.

Selection Criteria: We aimed to analyse separately unconfounded randomised controlled trials comparing thrombolytic agent with placebo, or thrombolytic agent with antithrombotic therapy, or thrombolytic agent and antithrombotic with antithrombotic alone, in patients with dural sinus thrombosis (confirmed by MR venography, intra-arterial venography or CT venography).

Data Collection And Analysis: Two groups of reviewers independently applied the inclusion criteria.

Main Results: No randomised controlled trials were found.

Reviewer's Conclusions: There is currently no available evidence from randomised controlled trials regarding the efficacy or safety of thrombolytic therapy in dural sinus thrombosis. A randomised controlled trial is justified to test this therapy especially in patients predicted to have a poor prognosis.

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