Using Gene Expression Arrays to Elucidate Transcriptional Profiles Underlying Prolactin Function

Overview

Journal J Mammary Gland Biol Neoplasia

Date 2004 Feb 20

PMID 14973373

Citations 16

Authors

Sandra Gass

Jessica Harris

Chris Ormandy

Cathrin Brisken

Affiliations

Soon will be listed here.

Abstract

Prolactin is an ancient hormone, with different functions in many species. The binding of prolactin to its receptor, a member of the cytokine receptor superfamily, results in the activation of different intracellular signaling pathways, such as JAK2/STAT5, MAP kinase, and PI3K/AKT. How prolactin elicits so many different biological responses remains unclear. Recently, microarray technology has been applied to identify prolactin target genes in different systems. Here, we attempt to summarize and compare the available data. Our comparison of the genes reported to be transcriptionally regulated by prolactin indicates that there are few genes in common between the different tissues. Among the organs studied, mammary and prostate glands displayed the largest number of overlaps in putative prolactin target genes. Some of the candidates have been implicated in tumorigenesis. The relevance and validation of microarray data, as well as comparison of the results obtained by different groups, will be discussed.

Citing Articles

: A Review of Ethnomedicinal, Phytochemical, Pharmacological, and Toxicological Findings.

Tian M, Huang Y, Wang X, Cao M, Zhao Z, Chen T Front Chem. 2021; 9:666280.

PMID: 33996757 PMC: 8117358. DOI: 10.3389/fchem.2021.666280.

Effect of Falcaria Vulgaris on Milk Production Parameters in Female Rats' Mammary Glands.

Salahshoor M, Mohammadi M, Roshankhah S, Jalili C J Family Reprod Health. 2019; 12(4):177-183.

PMID: 31239844 PMC: 6581660.

Prosocial effects of prolactin in male rats: Social recognition, social approach and social learning.

Donhoffner M, Al Saleh S, Schink O, Wood R Horm Behav. 2017; 96:122-129.

PMID: 28935447 PMC: 5722671. DOI: 10.1016/j.yhbeh.2017.09.011.

Elevated collagen-I augments tumor progressive signals, intravasation and metastasis of prolactin-induced estrogen receptor alpha positive mammary tumor cells.

Barcus C, OLeary K, Brockman J, Rugowski D, Liu Y, Garcia N Breast Cancer Res. 2017; 19(1):9.

PMID: 28103936 PMC: 5244528. DOI: 10.1186/s13058-017-0801-1.

Prolactin signaling through focal adhesion complexes is amplified by stiff extracellular matrices in breast cancer cells.

Barcus C, Keely P, Eliceiri K, Schuler L Oncotarget. 2016; 7(30):48093-48106.

PMID: 27344177 PMC: 5217003. DOI: 10.18632/oncotarget.10137.

References

Tu Z, Kollander R, Kiang D . Differential up-regulation of gap junction connexin 26 gene in mammary and uterine tissues: the role of Sp transcription factors. Mol Endocrinol. 1998; 12(12):1931-8. DOI: 10.1210/mend.12.12.0208. View

Clevenger C, Furth P, Hankinson S, Schuler L . The role of prolactin in mammary carcinoma. Endocr Rev. 2003; 24(1):1-27. PMC: 1698952. DOI: 10.1210/er.2001-0036. View

Hovey R, Harris J, Hadsell D, Lee A, Ormandy C, Vonderhaar B . Local insulin-like growth factor-II mediates prolactin-induced mammary gland development. Mol Endocrinol. 2003; 17(3):460-71. DOI: 10.1210/me.2002-0214. View

Lea I, Sivashanmugam P, ORand M . Zonadhesin: characterization, localization, and zona pellucida binding. Biol Reprod. 2001; 65(6):1691-700. DOI: 10.1095/biolreprod65.6.1691. View

Mackay A, Jones C, Dexter T, Silva R, Bulmer K, Jones A . cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells. Oncogene. 2003; 22(17):2680-8. DOI: 10.1038/sj.onc.1206349. View

Hrachovy J, Stevens A, Schwarz L . Interferon-regulatory factor 1 is an immediate-early gene under transcriptional regulation by prolactin in Nb2 T cells. Mol Cell Biol. 1990; 10(6):3087-94. PMC: 360673. DOI: 10.1128/mcb.10.6.3087-3094.1990. View

Roberts K, Hoffman L, Ensrud K, Hamilton D . Expression of crisp-1 mRNA splice variants in the rat epididymis, and comparative analysis of the rat and mouse crisp-1 gene regulatory regions. J Androl. 2001; 22(1):157-63. View

Brisken C, Ayyannan A, Nguyen C, Heineman A, Reinhardt F, Tan J . IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Dev Cell. 2002; 3(6):877-87. DOI: 10.1016/s1534-5807(02)00365-9. View

Fujitani Y, Masuho Y, MURAMATU M, Wakao H . Prolactin enhances CCAAT enhancer-binding protein-beta (C/EBP beta) and peroxisome proliferator-activated receptor gamma (PPAR gamma) messenger RNA expression and stimulates adipogenic conversion of NIH-3T3 cells. Mol Endocrinol. 2000; 14(2):307-16. DOI: 10.1210/mend.14.2.0420. View

10.

Vomachka A, Pratt S, Lockefeer J, Horseman N . Prolactin gene-disruption arrests mammary gland development and retards T-antigen-induced tumor growth. Oncogene. 2000; 19(8):1077-84. DOI: 10.1038/sj.onc.1203348. View

11.

Kenney N, Smith G, Rosenberg K, Cutler M, Dickson R . Induction of ductal morphogenesis and lobular hyperplasia by amphiregulin in the mouse mammary gland. Cell Growth Differ. 1996; 7(12):1769-81. View

12.

Ormandy C, Camus A, Barra J, Damotte D, Lucas B, Buteau H . Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev. 1997; 11(2):167-78. DOI: 10.1101/gad.11.2.167. View

13.

Williams L, McDonald C, Higgins S . Sequence organisation of rat seminal vesicle F gene: location of transcriptional start point and sequence comparison with six other androgen-regulated genes. Nucleic Acids Res. 1985; 13(3):659-72. PMC: 341026. DOI: 10.1093/nar/13.3.659. View

14.

Fantl V, Edwards P, Steel J, Vonderhaar B, Dickson C . Impaired mammary gland development in Cyl-1(-/-) mice during pregnancy and lactation is epithelial cell autonomous. Dev Biol. 1999; 212(1):1-11. DOI: 10.1006/dbio.1999.9329. View

15.

Hasskarl J, Munger K . Id proteins--tumor markers or oncogenes?. Cancer Biol Ther. 2002; 1(2):91-6. DOI: 10.4161/cbt.50. View

16.

Hovey R, Trott J, Ginsburg E, GOLDHAR A, Sasaki M, Fountain S . Transcriptional and spatiotemporal regulation of prolactin receptor mRNA and cooperativity with progesterone receptor function during ductal branch growth in the mammary gland. Dev Dyn. 2001; 222(2):192-205. DOI: 10.1002/dvdy.1179. View

17.

Das S, Chakraborty I, Paria B, Wang X, Plowman G, Dey S . Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus. Mol Endocrinol. 1995; 9(6):691-705. DOI: 10.1210/mend.9.6.8592515. View

18.

DeOME K, FAULKIN Jr L, Bern H, Blair P . Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Res. 1959; 19(5):515-20. View

19.

Naylor M, Ginsburg E, Iismaa T, Vonderhaar B, Wynick D, Ormandy C . The neuropeptide galanin augments lobuloalveolar development. J Biol Chem. 2003; 278(31):29145-52. DOI: 10.1074/jbc.M303746200. View

20.

Franchimont P, Dourcy C, Legros J, Reuter A, Van Cauwenberge J, Gaspard U . Prolactin levels during the menstrual cycle. Clin Endocrinol (Oxf). 1976; 5(6):643-50. DOI: 10.1111/j.1365-2265.1976.tb03867.x. View