Molecular Mechanisms of Arsenic Carcinogenesis

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2004 Feb 20

PMID 14971646

Citations 80

Authors

Chuanshu Huang

Qingdong Ke

Max Costa

Xianglin Shi

Affiliations

Soon will be listed here.

Abstract

Arsenic is a metalloid compound that is widely distributed in the environment. Human exposure of this compound has been associated with increased cancer incidence. Although the exact mechanisms remain to be investigated, numerous carcinogenic pathways have been proposed. Potential carcinogenic actions for arsenic include oxidative stress, genotoxic damage, DNA repair inhibition, epigenetic events, and activation of certain signal transduction pathways leading to abberrant gene expression. In this article, we summarize current knowledge on the molecular mechanisms of arsenic carcinogenesis with an emphasis on ROS and signal transduction pathways.

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