Adenocarcinoma Arising in Gastric Heterotopic Pancreas: a Case Report

Overview

Journal J Korean Med Sci

Specialty General Medicine

Date 2004 Feb 18

PMID 14966359

Citations 23

Authors

Dong Eun Song

Youngmee Kwon

Kyu Rae Kim

Sung Tae Oh

Jung Sun Kim

Affiliations

Soon will be listed here.

Abstract

A heterotopic pancreas in the gastrointestinal tract is mostly found incidentally and its malignant transformation is extremely rare. We describe the second case of adenocarcinoma arising in a gastric heterotopic pancreas of an asymptomatic 35-yr-old man in Korea. Esophagogastroduodenoscopy revealed a submucosal tumor with an irregular central umbilication in the gastric antrum. A wedge resection specimen demonstrated a submucosal oligolocular cystic mass (1.7 x 1.4 x 1.2 cm) with a solid portion. Microscopically, the cystic portion was composed of dilated pancreaticobiliary type ducts with adjacent small foci of periductal glandular structures. The adenocarcinoma components in the solid area infiltrated the proper muscle and the overlying mucosa of the stomach. The transitional area between the benign ductal structures and the adenocarcinoma component was found. The follow-up course was uneventful 5 months postoperatively.

Citing Articles

A Case Report of an Unusually Large Heterotopic Pancreas.

Iwuagwu C, Jensen L, Parikh J, Zayat V Cureus. 2024; 16(7):e64228.

PMID: 39007019 PMC: 11239240. DOI: 10.7759/cureus.64228.

Gastric ectopic pancreas adenocarcinoma: A case report and literature review.

Qian L, Yang J, Zhang J Saudi Med J. 2023; 44(11):1174-1179.

PMID: 37926464 PMC: 10712774. DOI: 10.15537/smj.2023.44.11.20220914.

Aberrant pancreas adenocarcinoma in the stomach: A case report and literature review.

Petrauskas V, Stulpinas R, Mickys U, Luksaite-Lukste R, Strupas K, Poskus E Medicine (Baltimore). 2023; 102(2):e32642.

PMID: 36637936 PMC: 9839233. DOI: 10.1097/MD.0000000000032642.

The malignancy among gastric submucosal tumor.

Yang B, Lu X Transl Cancer Res. 2022; 8(7):2654-2666.

PMID: 35117022 PMC: 8798018. DOI: 10.21037/tcr.2019.10.41.

Asymptomatic gastric adenomyoma and heterotopic pancreas in a patient with pancreatic cancer: A case report and review of the literature.

Li K, Xu Y, Liu N, Shi B World J Clin Cases. 2021; 9(27):8147-8156.

PMID: 34621874 PMC: 8462214. DOI: 10.12998/wjcc.v9.i27.8147.

References

Duval J, Savas L, Banner B . Expression of cytokeratins 7 and 20 in carcinomas of the extrahepatic biliary tract, pancreas, and gallbladder. Arch Pathol Lab Med. 2000; 124(8):1196-200. DOI: 10.5858/2000-124-1196-EOCAIC. View

Osanai M, Miyokawa N, Tamaki T, Yonekawa M, Kawamura A, Sawada N . Adenocarcinoma arising in gastric heterotopic pancreas: clinicopathological and immunohistochemical study with genetic analysis of a case. Pathol Int. 2001; 51(7):549-54. DOI: 10.1046/j.1440-1827.2001.01240.x. View

Qizilbash A . Acute pancreatitis occurring in heterotopic pancreatic tissue in the gallbladder. Can J Surg. 1976; 19(5):413-4. View

Caberwal D, Kogan S, Levitt S . Ectopic pancreas presenting as an umbilical mass. J Pediatr Surg. 1977; 12(4):593-9. DOI: 10.1016/0022-3468(77)90207-x. View

HICKMAN D, Frey C, Carson J . Adenocarcinoma arising in gastric heterotopic pancreas. West J Med. 1981; 135(1):57-62. PMC: 1272925. View

Kaneda M, Yano T, Yamamoto T, Suzuki T, Fujimori K, Itoh H . Ectopic pancreas in the stomach presenting as an inflammatory abdominal mass. Am J Gastroenterol. 1989; 84(6):663-6. View

Makhlouf H, Almeida J, Sobin L . Carcinoma in jejunal pancreatic heterotopia. Arch Pathol Lab Med. 1999; 123(8):707-11. DOI: 10.5858/1999-123-0707-CIJPH. View

Ishikawa O, Ishiguro S, Ohhigashi H, Sasaki Y, Yasuda T, Imaoka S . Solid and papillary neoplasm arising from an ectopic pancreas in the mesocolon. Am J Gastroenterol. 1990; 85(5):597-601. View

Jeng K, Yang K, Kuo S . Malignant degeneration of heterotopic pancreas. Gastrointest Endosc. 1991; 37(2):196-8. DOI: 10.1016/s0016-5107(91)70687-1. View

10.

St-Vil D, Brandt M, Panic S, Bensoussan A, Blanchard H . Meckel's diverticulum in children: a 20-year review. J Pediatr Surg. 1991; 26(11):1289-92. DOI: 10.1016/0022-3468(91)90601-o. View

11.

Kneafsey P, Demetrick D . Malignant transformation in a pyloric adenomyoma: a case report. Histopathology. 1992; 20(5):433-5. DOI: 10.1111/j.1365-2559.1992.tb01015.x. View

12.

Herold G, Kraft K . Adenocarcinoma arising from ectopic gastric pancreas: two case reports with a review of the literature. Z Gastroenterol. 1995; 33(5):260-4. View

13.

Chapple C, Muller S, Newman J . Gastric adenocarcinoma associated with adenomyoma of the stomach. Postgrad Med J. 1988; 64(756):801-3. PMC: 2429027. DOI: 10.1136/pgmj.64.756.801. View