The Role of Organic Ion Transporters in Drug Disposition: an Update

Overview

Journal Curr Drug Metab

Publisher Bentham Science Publishers

Specialties Chemistry
Endocrinology

Date 2004 Feb 18

PMID 14965250

Citations 19

Authors

Guofeng You

Affiliations

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Abstract

Transporters for organic anions and organic cations in kidney, liver, intestine, brain, and placenta play essential roles in drug disposition. The cloning and characterization of these transporters have significantly advanced our understanding of the molecular and cellular mechanisms of the drug disposition process. This review aims at updating the recent knowledge of general properties, structure-function relationships, and regulation mechanisms of the organic anion transporters (OATs) and the organic cation transporters (OCTs). Such information will be essential for the design and development of new drugs to maximize therapeutic efficacy and minimize drug-induced toxicity as well as unwanted drug-drug interactions.

Citing Articles

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Berberine-induced Inactivation of Signal Transducer and Activator of Transcription 5 Signaling Promotes Male-specific Expression of a Bile Acid Uptake Transporter.

Bu P, Le Y, Zhang Y, Zhang Y, Cheng X J Biol Chem. 2017; 292(11):4602-4613.

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Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins.

Yin J, Duan H, Shirasaka Y, Prasad B, Wang J Drug Metab Dispos. 2015; 43(12):1872-81.

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Immunohistochemical analysis of organic anion transporter 2 and reduced folate carrier 1 in colorectal cancer: Significance as a predictor of response to oral uracil/ftorafur plus leucovorin chemotherapy.

Nishino S, Itoh A, Matsuoka H, Maeda K, Kamoshida S Mol Clin Oncol. 2014; 1(4):661-667.

PMID: 24649225 PMC: 3916200. DOI: 10.3892/mco.2013.104.

Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures.

Dahlin A, Geier E, Stocker S, Cropp C, Grigorenko E, Bloomer M Mol Pharm. 2012; 10(2):650-63.

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