Role of Indoleamine-2,3-dioxygenase in Alpha/beta and Gamma Interferon-mediated Antiviral Effects Against Herpes Simplex Virus Infections

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2004 Feb 14

PMID 14963171

Citations 54

Authors

O Adams

K Besken

C Oberdorfer

C R MacKenzie

O Takikawa

W Daubener

Affiliations

Soon will be listed here.

Abstract

Gamma interferon (IFN-gamma)-mediated indoleamine-2,3-dioxygenase (IDO) activity in human astrocytoma cells and in native astrocytes was found to be responsible for the inhibition of herpes simplex virus replication. The effect is abolished in the presence of excess amounts of L-tryptophan. Both IFN-alpha and IFN-beta restricted herpes simplex virus replication in both cell types, but (in contrast to the results seen with IFN-gamma) the addition of an excess amount of L-tryptophan did not inhibit the induced antiviral effect.

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