Correlations Between Theophylline Concentrations in Plasma, Erythrocytes and Cantharides-induced Blister Fluid and Peak Expiratory Flow in Asthma Patients

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1992 Jan 1

PMID 1483497

Citations 3

Authors

F Philip-Joet

B Bruguerolle

M Reynaud

A Arnaud

Affiliations

Soon will be listed here.

Abstract

Theophylline levels in plasma, erythrocytes and cantharides-induced blister fluid (BF) have been correlated with peak expiratory flow (PEF) in asthmatic patients. Nine asthmatic men received an IV infusion of 240 mg theophylline at a constant rate for 30 min. The theophylline concentrations in erythrocytes and blister fluid were 37% and 78% of those in plasma. There was not a strong correlation between erythrocyte or blister fluid penetration and the clinical effect of theophylline.

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Human subcutaneous tissue distribution of fluconazole: comparison of microdialysis and suction blister techniques.

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Direct assessment of peripheral pharmacokinetics in humans: comparison between cantharides blister fluid sampling, in vivo microdialysis and saliva sampling.

Brunner M, Schmiedberger A, Schmid R, Jager D, Piegler E, Eichler H Br J Clin Pharmacol. 1998; 46(5):425-31.

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Theophylline kinetics in peripheral tissues in vivo in humans.

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References

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