Variation of Chemical Composition with Age in Human Femoral Head Cartilage

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 1978 Apr 1

PMID 148244

Citations 23

Authors

M F Venn

Affiliations

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Abstract

The chemical composition of intact femoral head cartilage was investigated with age. Full-depth cartilage showed a decrease in water content and an increase in keratan sulphate and noncollagenous material with age. When analyzed through the depth of the cartilage, keratan sulphate was shown to appear first in the deep zones and later in the surface, while water content was lost mainly in the deep zones. On a dry weight basis collagen content decreased with age. This was not a real loss but was due to a change in the proportions of other materials, mainly in the deep zones.

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References

Venn M, Maroudas A . Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition. Ann Rheum Dis. 1977; 36(2):121-9. PMC: 1006646. DOI: 10.1136/ard.36.2.121. View

Maroudas A . Biophysical chemistry of cartilaginous tissues with special reference to solute and fluid transport. Biorheology. 1975; 12(3-4):233-48. DOI: 10.3233/bir-1975-123-416. View

VON BERLEPSCH K . Two automated procedures for determination of uronic acid in acid glycosaminoglycans. Anal Biochem. 1969; 27(3):424-32. DOI: 10.1016/0003-2697(69)90056-6. View

Stockwell R . Changes in the acid glycosaminoglycan content of the matrix of ageing human articular cartilage. Ann Rheum Dis. 1970; 29(5):509-15. PMC: 1010565. DOI: 10.1136/ard.29.5.509. View

Maroudas A, Thomas H . A simple physicochemical micromethod for determining fixed anionic groups in connective tissue. Biochim Biophys Acta. 1970; 215(1):214-6. View

HJERTQUIST S, LEMPERG R . Identification and concentration of the glycosaminoglycans of human articular cartilage in relation to age and osteoarthritis. Calcif Tissue Res. 1972; 10(3):223-37. DOI: 10.1007/BF02012552. View

Maroudas A, Evans H, Almeida L . Cartilage of the hip joint. Topographical variation of glycosaminoglycan content in normal and fibrillated tissue. Ann Rheum Dis. 1973; 32(1):1-9. PMC: 1006025. DOI: 10.1136/ard.32.1.1. View

LEMPERG R, Larsson S, HJERTQUIST S . The glycosaminoglycans of bovine articular cartilage. I. Concentration and distribution in different layers in relation to age. Calcif Tissue Res. 1974; 15(3):237-51. DOI: 10.1007/BF02059060. View

Bjelle A . Variations in content and composition of glycosaminoglycans within the articular cartilage of the lower femoral epiphysis of an adult. A pilot study. Scand J Rheumatol. 1974; 3(2):81-8. DOI: 10.3109/03009747409115806. View

10.

CAMPO R, TOURTELLOTTE C . The composition of bovine cartilage and bone. Biochim Biophys Acta. 1967; 141(3):614-24. DOI: 10.1016/0304-4165(67)90190-0. View

11.

HJERTQUIST S, Wasteson A . The molecular weight of chondroitin sulphate from human articular cartilage. Effect of age and of osteoarthritis. Calcif Tissue Res. 1972; 10(1):31-7. DOI: 10.1007/BF02012533. View

12.

Byers P, Contepomi C, Farkas T . A post mortem study of the hip joint. Including the prevalence of the features of the right side. Ann Rheum Dis. 1970; 29(1):15-31. PMC: 1031217. DOI: 10.1136/ard.29.1.15. View

13.

Rosenberg L, Johnson B, Schubert M . Proteinpolysaccharides from human articular and costal cartilage. J Clin Invest. 1965; 44(10):1647-56. PMC: 292649. DOI: 10.1172/JCI105271. View

14.

Sokoloff L . Elasticity of aging cartilage. Fed Proc. 1966; 25(3):1089-95. View

15.

HJERTQUIST S, LEMPERG R . Studies of autologous diced costal cartilage transplant. 3. With special regard to glycosaminoglycans, hydroxyproline, calcium and 35S-sulphate incorporation in vitro after intramuscular implantation. Acta Soc Med Ups. 1967; 72(3):173-98. View

16.

STEGEMANN H . [Microdetermination of hydroxyproline with chloramine-T and p-dimethylaminobenzaldehyde]. Hoppe Seylers Z Physiol Chem. 1958; 311(1-3):41-5. View

17.

KAPLAN D, Meyer K . Ageing of human cartilage. Nature. 1959; 183(4670):1267-8. DOI: 10.1038/1831267a0. View

18.

Collins D, MEACHIM G . Sulphate (35SO4) fixation by human articular cartilage compared in the knee and shoulder joints. Ann Rheum Dis. 1961; 20:117-22. PMC: 1007194. DOI: 10.1136/ard.20.2.117. View

19.

Bitter T, MUIR H . A modified uronic acid carbazole reaction. Anal Biochem. 1962; 4:330-4. DOI: 10.1016/0003-2697(62)90095-7. View

20.

Miles J, EICHELBERGER L . BIOCHEMICAL STUDIES OF HUMAN CARTILAGE DURING THE AGING PROCESS. J Am Geriatr Soc. 1964; 12:1-20. DOI: 10.1111/j.1532-5415.1964.tb01535.x. View