Significant Changes of Peripheral T Lymphocyte Subsets in Patients with Severe Acute Respiratory Syndrome

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2004 Feb 10

PMID 14767818

Citations 170

Authors

Taisheng Li

Zhifeng Qiu

Linqi Zhang

Yang Han

Wei He

Zhengyin Liu

Xiaojun Ma

Hongwei Fan

Wei Lu

Jing Xie

Huanling Wang

Guohua Deng

Aixia Wang

Affiliations

Soon will be listed here.

Abstract

This report demonstrates that a rapid decrease of peripheral T cell subsets is a unique characteristic in patients with SARS during acute infection, although total white blood cell counts, red blood cell counts, and platelet counts remain relatively normal. In recovering patients, a rapid and dramatic restoration of peripheral T cell subsets was seen in the periphery. Although the underlying mechanism of the acute decrease of peripheral T cell subsets observed in patients with SARS during the acute stage remains unknown, this clinical characteristic can facilitate an earlier and more accurate diagnosis of SARS.

Citing Articles

HCG18, LEF1AS1 and lncCEACAM21 as biomarkers of disease severity in the peripheral blood mononuclear cells of COVID-19 patients.

Greco S, Made A, Mutoli M, Zhang L, Piella S, Vausort M J Transl Med. 2023; 21(1):758.

PMID: 37884975 PMC: 10605335. DOI: 10.1186/s12967-023-04497-6.

Potential biomarkers for fatal outcome prognosis in a cohort of hospitalized COVID-19 patients with pre-existing comorbidities.

Madera-Sandoval R, Cerbulo-Vazquez A, Arriaga-Pizano L, Cabrera-Rivera G, Basilio-Galvez E, Miranda-Cruz P Clin Transl Sci. 2023; 16(12):2687-2699.

PMID: 37873554 PMC: 10719476. DOI: 10.1111/cts.13663.

Leukopenia and leukocytosis as strong predictors of COVID-19 severity: A cross-sectional study of the hematologic abnormalities and COVID-19 severity in hospitalized patients.

Sharafi F, Esfehani R, Moodi Ghalibaf A, Jarahi L, Shamshirian A, Mozdourian M Health Sci Rep. 2023; 6(10):e1574.

PMID: 37779668 PMC: 10533955. DOI: 10.1002/hsr2.1574.

Age-dependent immune responses in COVID-19-mediated liver injury: focus on cytokines.

Aghamohamadi N, Shahba F, Mehrabadi A, Khorramdelazad H, Karimi M, Falak R Front Endocrinol (Lausanne). 2023; 14:1139692.

PMID: 37654571 PMC: 10465349. DOI: 10.3389/fendo.2023.1139692.

Clinico-Epidemiological Laboratory Findings of COVID- 19 Positive Patients in a Hospital in Saudi Arabia.

Elhag W, Elamin B, Idris E, Elsheikh A, Ghaleb K, Fallatah I Infect Drug Resist. 2023; 16:4845-4856.

PMID: 37520449 PMC: 10386838. DOI: 10.2147/IDR.S418629.

References

Li T, Tubiana R, Fillet A, Autran B, Katlama C . Negative result of cytomegalovirus blood culture with restoration of CD4+ T-cell reactivity to cytomegalovirus after HAART in an HIV-1-infected patient. J Acquir Immune Defic Syndr Hum Retrovirol. 1999; 20(5):514-5. DOI: 10.1097/00042560-199904150-00016. View

ODonnell D, Carrington D . Peripheral blood lymphopenia and neutrophilia in children with severe respiratory syncytial virus disease. Pediatr Pulmonol. 2002; 34(2):128-30. DOI: 10.1002/ppul.10140. View

Drosten C, Gunther S, Preiser W, van der Werf S, Brodt H, Becker S . Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003; 348(20):1967-76. DOI: 10.1056/NEJMoa030747. View

Poutanen S, Low D, Henry B, Finkelstein S, Rose D, Green K . Identification of severe acute respiratory syndrome in Canada. N Engl J Med. 2003; 348(20):1995-2005. DOI: 10.1056/NEJMoa030634. View

Bautista E, Ferman G, Golde W . Induction of lymphopenia and inhibition of T cell function during acute infection of swine with foot and mouth disease virus (FMDV). Vet Immunol Immunopathol. 2003; 92(1-2):61-73. DOI: 10.1016/s0165-2427(03)00004-7. View

Fouchier R, Kuiken T, Schutten M, van Amerongen G, van Doornum G, van den Hoogen B . Aetiology: Koch's postulates fulfilled for SARS virus. Nature. 2003; 423(6937):240. PMC: 7095368. DOI: 10.1038/423240a. View

Callan M . The evolution of antigen-specific CD8+ T cell responses after natural primary infection of humans with Epstein-Barr virus. Viral Immunol. 2003; 16(1):3-16. DOI: 10.1089/088282403763635401. View

Rota P, Oberste M, Monroe S, Nix W, Campagnoli R, Icenogle J . Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science. 2003; 300(5624):1394-9. DOI: 10.1126/science.1085952. View

Tsang K, Ho P, Ooi G, Yee W, Wang T, Chan-Yeung M . A cluster of cases of severe acute respiratory syndrome in Hong Kong. N Engl J Med. 2003; 348(20):1977-85. DOI: 10.1056/NEJMoa030666. View

10.

Zitzow L, Rowe T, Morken T, Shieh W, Zaki S, Katz J . Pathogenesis of avian influenza A (H5N1) viruses in ferrets. J Virol. 2002; 76(9):4420-9. PMC: 155091. DOI: 10.1128/jvi.76.9.4420-4429.2002. View

11.

Ksiazek T, Erdman D, Goldsmith C, Zaki S, Peret T, Emery S . A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003; 348(20):1953-66. DOI: 10.1056/NEJMoa030781. View

12.

Booth C, Matukas L, Tomlinson G, Rachlis A, Rose D, Dwosh H . Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. JAMA. 2003; 289(21):2801-9. DOI: 10.1001/jama.289.21.JOC30885. View

13.

Holmes K . SARS-associated coronavirus. N Engl J Med. 2003; 348(20):1948-51. DOI: 10.1056/NEJMp030078. View

14.

Li T, Tubiana R, Katlama C, Calvez V, Ait Mohand H, Autran B . Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease. Lancet. 1998; 351(9117):1682-6. DOI: 10.1016/s0140-6736(97)10291-4. View

15.

Lee N, Hui D, Wu A, Chan P, Cameron P, Joynt G . A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med. 2003; 348(20):1986-94. DOI: 10.1056/NEJMoa030685. View

16.

Peiris J, Chu C, Cheng V, Chan K, Hung I, Poon L . Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet. 2003; 361(9371):1767-72. PMC: 7112410. DOI: 10.1016/s0140-6736(03)13412-5. View

17.

Okada H, Kobune F, Sato T, Kohama T, Takeuchi Y, Abe T . Extensive lymphopenia due to apoptosis of uninfected lymphocytes in acute measles patients. Arch Virol. 2000; 145(5):905-20. DOI: 10.1007/s007050050683. View

18.

Looney R, Falsey A, Campbell D, Torres A, Kolassa J, Brower C . Role of cytomegalovirus in the T cell changes seen in elderly individuals. Clin Immunol. 1999; 90(2):213-9. DOI: 10.1006/clim.1998.4638. View

19.

Kuijpers T, Vossen M, Gent M, Davin J, Roos M, Wertheim-Van Dillen P . Frequencies of circulating cytolytic, CD45RA+CD27-, CD8+ T lymphocytes depend on infection with CMV. J Immunol. 2003; 170(8):4342-8. DOI: 10.4049/jimmunol.170.8.4342. View

20.

Autran B, Carcelain G, Li T, Blanc C, Mathez D, Tubiana R . Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science. 1997; 277(5322):112-6. DOI: 10.1126/science.277.5322.112. View