Comparison of Survival and Other Complications After Heart Transplantation in Patients Taking Amiodarone Before Surgery Versus Those Not Taking Amiodarone

Overview

Journal Am J Cardiol

Specialty Cardiology & Vascular Diseases

Date 2004 Feb 5

PMID 14759399

Citations 8

Authors

Patrick J Blomberg

Andrew D Feingold

David DeNofrio

William Rand

Marvin A Konstam

N A Mark Estes 3rd

Mark S Link

Affiliations

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Abstract

Concern exists regarding preoperative amiodarone use and complications occurring after heart transplantation (HT). During a 10-year period of performing HT, we found that patients treated with amiodarone before undergoing HT had decreased overall survival, required longer periods of ventilatory support, and were at increased risk for significant bleeding complications. These findings raise further concern about the use of amiodarone treatment in patients with heart failure before undergoing HT.

Citing Articles

Amiodarone Use Prior to Cardiac Transplant Impacts Early Post-Transplant Survival.

Allana S, Rajput F, Smith J, Lozonschi L, Liou J, Johnson M Cardiovasc Drugs Ther. 2020; 35(1):33-40.

PMID: 33074524 DOI: 10.1007/s10557-020-07092-9.

Combined amiodarone and digitalis therapy before heart transplantation is associated with increased post-transplant mortality.

Rivinius R, Helmschrott M, Rahm A, Darche F, Thomas D, Bruckner T ESC Heart Fail. 2020; 7(5):2082-2092.

PMID: 32608191 PMC: 7524115. DOI: 10.1002/ehf2.12807.

Control of cardiac chronotropic function in patients after heart transplantation: effects of ivabradine and metoprolol succinate on resting heart rate in the denervated heart.

Rivinius R, Helmschrott M, Ruhparwar A, Rahm A, Darche F, Thomas D Clin Res Cardiol. 2017; 107(2):138-147.

PMID: 29098378 DOI: 10.1007/s00392-017-1165-3.

Comparison of posttransplant outcomes in patients with no, acute, or chronic amiodarone use before heart transplantation.

Rivinius R, Helmschrott M, Ruhparwar A, Darche F, Thomas D, Bruckner T Drug Des Devel Ther. 2017; 11:1827-1837.

PMID: 28684901 PMC: 5484508. DOI: 10.2147/DDDT.S136948.

Amiodarone use in patients listed for heart transplant is associated with increased 1-year post-transplant mortality.

Cooper L, Mentz R, Edwards L, Wilk A, Rogers J, Patel C J Heart Lung Transplant. 2016; 36(2):202-210.

PMID: 27520780 PMC: 5241253. DOI: 10.1016/j.healun.2016.07.009.