90K (Mac-2 BP) and Galectins in Tumor Progression and Metastasis

Overview

Journal Glycoconj J

Publisher Springer

Specialties Biochemistry
Endocrinology

Date 2004 Feb 6

PMID 14758079

Citations 71

Authors

Antonino Grassadonia

Nicola Tinari

Ida Iurisci

Enza Piccolo

Alba Cumashi

Pasquale Innominato

Maurizia DEgidio

Clara Natoli

Mauro Piantelli

Stefano Iacobelli

Affiliations

Soon will be listed here.

Abstract

Galectins and their ligands have been implicated in cell transformation and cancer metastasis, and found to have prognostic value. Mac-2 BP, also known as 90K, is a highly glycosylated, secreted protein extensively studied in human cancer, which binds galectin-1, galectin-3 and galectin-7. High expression levels of 90K are associated with a shorter survival, the occurrence of metastasis or a reduced response to chemotherapy in patients with different types of malignancy. The mechanisms underlying the prognostic significance of 90K and galectins in cancer are far from being understood, although they may be related to the ability of these proteins to interact and, to some extent, modulate cell-cell and cell-matrix adhesion and apoptosis. The resulting scenario is even more complex, as data have been presented that all these proteins might be associated with either a positive or a negative outcome of the patients. It is hypothesised that different galectins and galectin ligands with overlapping or opposite functions, expressed in different tumors during the different steps of the metastatic cascade might play a crucial role in tumor progression.

Citing Articles

Impaired bisecting GlcNAc reprogrammed M1 polarization of macrophage.

He X, Wang B, Deng W, Cao J, Tan Z, Li X Cell Commun Signal. 2024; 22(1):73.

PMID: 38279161 PMC: 10811823. DOI: 10.1186/s12964-023-01432-6.

Plasma-Derived Exosome Proteins as Novel Diagnostic and Prognostic Biomarkers in Neuroblastoma Patients.

Morini M, Raggi F, Bartolucci M, Petretto A, Ardito M, Rossi C Cells. 2023; 12(21).

PMID: 37947594 PMC: 10649754. DOI: 10.3390/cells12212516.

Serum wisteria floribunda agglutinin-positive human Mac-2 binding protein is unsuitable as a diagnostic marker of occult hepatocellular carcinoma in end-stage liver cirrhosis.

Nagakawa K, Hidaka M, Hara T, Matsushima H, Imamura H, Tanaka T PLoS One. 2023; 18(11):e0293593.

PMID: 37910585 PMC: 10619783. DOI: 10.1371/journal.pone.0293593.

Spontaneous metastasis xenograft models link CD44 isoform 4 to angiogenesis, hypoxia, EMT and mitochondria-related pathways in colorectal cancer.

Everest-Dass A, Nersisyan S, Maar H, Novosad V, Schroder-Schwarz J, Freytag V Mol Oncol. 2023; 18(1):62-90.

PMID: 37849446 PMC: 10766209. DOI: 10.1002/1878-0261.13535.

Galectin-3 binding protein stimulated IL-6 expression is impeded by antibody intervention in SARS-CoV-2 susceptible cell lines.

Mendes-Frias A, Gallo V, Iacobelli V, Gentile R, Antonini G, Silvestre R Sci Rep. 2022; 12(1):17047.

PMID: 36220879 PMC: 9553085. DOI: 10.1038/s41598-022-20852-x.

References

Jallal B, Powell J, Zachwieja J, Brakebusch C, Germain L, Jacobs J . Suppression of tumor growth in vivo by local and systemic 90K level increase. Cancer Res. 1995; 55(15):3223-7. View

Hsu D, Dowling C, Jeng K, Chen J, Yang R, Liu F . Galectin-3 expression is induced in cirrhotic liver and hepatocellular carcinoma. Int J Cancer. 1999; 81(4):519-26. DOI: 10.1002/(sici)1097-0215(19990517)81:4<519::aid-ijc3>3.0.co;2-0. View

Idikio H . Galectin-3 expression in human breast carcinoma: correlation with cancer histologic grade. Int J Oncol. 1998; 12(6):1287-90. DOI: 10.3892/ijo.12.6.1287. View

Natoli C, Garufi C, Tinari N, DEgidio M, Lesti G, Gaspari L . Dynamic test with recombinant interferon-alpha-2b: effect on 90K and other tumour-associated antigens in cancer patients without evidence of disease. Br J Cancer. 1993; 67(3):564-7. PMC: 1968249. DOI: 10.1038/bjc.1993.103. View

Castronovo V, van den Brule F, Jackers P, Clausse N, Liu F, Gillet C . Decreased expression of galectin-3 is associated with progression of human breast cancer. J Pathol. 1996; 179(1):43-8. DOI: 10.1002/(SICI)1096-9896(199605)179:1<43::AID-PATH541>3.0.CO;2-N. View

Iacobelli S, Arno E, DOrazio A, Coletti G . Detection of antigens recognized by a novel monoclonal antibody in tissue and serum from patients with breast cancer. Cancer Res. 1986; 46(6):3005-10. View

Choufani G, Nagy N, Saussez S, Marchant H, Bisschop P, Burchert M . The levels of expression of galectin-1, galectin-3, and the Thomsen-Friedenreich antigen and their binding sites decrease as clinical aggressiveness increases in head and neck cancers. Cancer. 1999; 86(11):2353-63. DOI: 10.1002/(sici)1097-0142(19991201)86:11<2353::aid-cncr25>3.0.co;2-a. View

Zeimet A, Natoli C, Herold M, Fuchs D, Windbichler G, Daxenbichler G . Circulating immunostimulatory protein 90K and soluble interleukin-2-receptor in human ovarian cancer. Int J Cancer. 1996; 68(1):34-8. DOI: 10.1002/(SICI)1097-0215(19960927)68:1<34::AID-IJC7>3.0.CO;2-Y. View

Lahm H, Andre S, Hoeflich A, Fischer J, Sordat B, Kaltner H . Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures. J Cancer Res Clin Oncol. 2001; 127(6):375-86. DOI: 10.1007/s004320000207. View

10.

Iacobelli S, Arno E, Sismondi P, Natoli C, Gentiloni N, Scambia G . Measurement of a breast cancer associated antigen detected by monoclonal antibody SP-2 in sera of cancer patients. Breast Cancer Res Treat. 1988; 11(1):19-30. DOI: 10.1007/BF01807554. View

11.

Zhang D, Jiang W, Li S, Zhang X, Mao H, Chen X . [Predictive significance of serum 90K/Mac-2BP on chemotherapy response in non-Hodgkin's lymphoma]. Ai Zheng. 2003; 22(8):870-3. View

12.

Xu X, El-Naggar A, Lotan R . Differential expression of galectin-1 and galectin-3 in thyroid tumors. Potential diagnostic implications. Am J Pathol. 1995; 147(3):815-22. PMC: 1870977. View

13.

Woo H, Shaw L, Messier J, Mercurio A . The major non-integrin laminin binding protein of macrophages is identical to carbohydrate binding protein 35 (Mac-2). J Biol Chem. 1990; 265(13):7097-9. View

14.

Briggs N, Natoli C, Tinari N, DEgidio M, Goedert J, Iacobelli S . A 90-kDa protein serum marker for the prediction of progression to AIDS in a cohort of HIV-1+ homosexual men. AIDS Res Hum Retroviruses. 1993; 9(9):811-6. DOI: 10.1089/aid.1993.9.811. View

15.

Raz A, Lotan R . Endogenous galactoside-binding lectins: a new class of functional tumor cell surface molecules related to metastasis. Cancer Metastasis Rev. 1987; 6(3):433-52. DOI: 10.1007/BF00144274. View

16.

Chiariotti L, Berlingieri M, Battaglia C, Benvenuto G, Martelli M, Salvatore P . Expression of galectin-1 in normal human thyroid gland and in differentiated and poorly differentiated thyroid tumors. Int J Cancer. 1995; 64(3):171-5. DOI: 10.1002/ijc.2910640305. View

17.

Matarrese P, Tinari N, Semeraro M, Natoli C, Iacobelli S, Malorni W . Galectin-3 overexpression protects from cell damage and death by influencing mitochondrial homeostasis. FEBS Lett. 2000; 473(3):311-5. DOI: 10.1016/s0014-5793(00)01547-7. View

18.

Rea A, Palmieri G, Tinari N, Natoli C, Tagliaferri P, Morabito A . 90k is a serum marker of poor-prognosis in non-hodgkins-lymphoma patients. Oncol Rep. 2011; 1(4):723-5. DOI: 10.3892/or.1.4.723. View

19.

Koths K, Taylor E, Halenbeck R, Casipit C, Wang A . Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain. J Biol Chem. 1993; 268(19):14245-9. View

20.

Barondes S, Cooper D, Gitt M, Leffler H . Galectins. Structure and function of a large family of animal lectins. J Biol Chem. 1994; 269(33):20807-10. View