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Surgery for Primary Basal Cell Carcinoma Including the Eyelid Margins with Intraoperative Frozen Section Control: Comparative Interventional Study with a Minimum Clinical Follow Up of 5 Years

Overview
Journal Br J Ophthalmol
Specialty Ophthalmology
Date 2004 Jan 23
PMID 14736782
Citations 12
Authors
R M Conway
S Themel
L M Holbach
Affiliations
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Abstract

Aim: To assess recurrence of primary basal cell carcinoma (PBCC) including the eyelid margins after resection with or without intraoperative frozen section control (IFS).

Methods: Comparative non-randomised interventional study involving review of records of consecutive patients with histological diagnosis of PBCC including the eyelid margins, treated surgically at the University of Erlangen-Nürnberg between 1989 and 1998. Patients with a minimum clinical follow up of 5 years treated with (group I) or without (group II) IFS were compared. Postoperatively, permanent paraffin sections were available in all patients.

Results: 165 patients were available for study. There were 145 patients with a minimum of 5 years follow up. Of these, no tumour recurrences were observed in group I (n = 114) compared with three (9.7%) in group II (n = 31) (p = 0.002).

Conclusions: Surgery for PBCC including the eyelid margins with IFS and immediate plastic reconstruction, as performed in the present study, is associated with better long term cure compared with surgery with clinical control.

Citing Articles

Recurrence of Basal Cell Carcinoma Treated with Surgical Excision and Histopathological Analysis with Frozen Section Technique with Complete Margin Control (CMC-FS): A 15-Year Experience of a Reference Center.

Di Maria A, Barone G, Ferraro V, Tredici C, Manara S, De Carlo C Cancers (Basel). 2023; 15(15).

PMID: 37568656 PMC: 10417263. DOI: 10.3390/cancers15153840.

Periocular basal cell carcinoma results and surgical outcome during a 5-year period in a larger Danish population.

Karlsdottir S, Johannessen S, Bjerrum N, Frydkjaer-Olsen U, Blindbaek S, Moller F BMC Ophthalmol. 2022; 22(1):282.

PMID: 35761210 PMC: 9237979. DOI: 10.1186/s12886-022-02494-9.

Use of Intraoperative Frozen Section in the Surgical Management of Patients with Nonmelanoma Skin Cancer.

Loh L, Tiwari P, Lee J, Low O, Nallathamby V, Lee H J Skin Cancer. 2021; 2021:4944570.

PMID: 34760320 PMC: 8575635. DOI: 10.1155/2021/4944570.

Rapid brain structure and tumour margin detection on whole frozen tissue sections by fast multiphotometric mid-infrared scanning.

Kummel T, van Marwick B, Rittel M, Ramallo Guevara C, Wuhler F, Teumer T Sci Rep. 2021; 11(1):11307.

PMID: 34050224 PMC: 8163866. DOI: 10.1038/s41598-021-90777-4.

Periocular Basal Cell Carcinoma: 20-Years Experience at a Tertiary Eye Care Center of South India.

Vijay V, Alam M, Subramanian N, Krishnakumar S, Biswas J, Mukherjee B Oman J Ophthalmol. 2021; 13(3):129-135.

PMID: 33542600 PMC: 7852420. DOI: 10.4103/ojo.OJO_130_2019.

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