Prolongation of Life Span Associated with Immunological Modification by Chronic Low-dose-rate Irradiation in MRL-lpr/lpr Mice

Overview

Journal Radiat Res

Specialties Genetics
Radiology

Date 2004 Jan 21

PMID 14731073

Citations 23

Authors

Yasuhiro Ina

Kazuo Sakai

Affiliations

Soon will be listed here.

Abstract

Chronic low-dose-rate gamma irradiation at 0.35 or 1.2 mGy/h prolonged the life span of MRL-lpr/lpr mice carrying a deletion in the apoptosis-regulating Fas gene that markedly shortens life due to severe autoimmune disease. Immunological modifications as indicated by a significant increase of CD8(+) T cells and a significant decrease of CD3(+) CD45R/B220(+) as well as CD45R/B220(+) CD40(+) cells were found in parallel with amelioration of total-body lymphadenopathy, splenomegaly, proteinuria, and kidney and brain syndromes.

Citing Articles

Effects of exposing Japanese quail eggs to a low dose of gamma radiation and in ovo feeding by two sources of trace elements on embryonic development activities.

Hatab M, Chen W, Abouelezz K, Elaroussi M, Badran A, Zoheir K Poult Sci. 2024; 103(3):103364.

PMID: 38198914 PMC: 10825557. DOI: 10.1016/j.psj.2023.103364.

Radiation as a Tool against Neurodegeneration-A Potential Treatment for Amyloidosis in the Central Nervous System.

Coelho C, Pereira L, Teubig P, Santos P, Mendes F, Vinals S Int J Mol Sci. 2022; 23(20).

PMID: 36293118 PMC: 9603404. DOI: 10.3390/ijms232012265.

Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders.

Vaiserman A, Cuttler J, Socol Y Biogerontology. 2021; 22(2):145-164.

PMID: 33420860 PMC: 7794644. DOI: 10.1007/s10522-020-09908-5.

Ionizing Radiation and Translation Control: A Link to Radiation Hormesis?.

Kabilan U, Graber T, Alain T, Klokov D Int J Mol Sci. 2020; 21(18).

PMID: 32932812 PMC: 7555331. DOI: 10.3390/ijms21186650.

Effects of low dose radiation on immune cells subsets and cytokines in mice.

Liu X, Liu Z, Wang D, Han Y, Hu S, Xie Y Toxicol Res (Camb). 2020; 9(3):249-262.

PMID: 32670556 PMC: 7329176. DOI: 10.1093/toxres/tfaa017.