Helicobacter Pylori Eradication Does Not Exacerbate Gastro-oesophageal Reflux Disease

Overview

Journal Gut

Specialty Gastroenterology

Date 2004 Jan 16

PMID 14724171

Citations 4

Authors

P Malfertheiner

Affiliations

Soon will be listed here.

Abstract

The reciprocal influence of Helicobacter pylori infection and gastro-oesophageal reflux disease (GORD), if both conditions occur concomitantly, has been an issue of debate for many years. The critical question is whether eradication of H pylori has a more beneficial, harmful, or simply no effect on the course of GORD.

Citing Articles

The relationship between helicobacter pylori infection and gastro-esophageal reflux disease.

Mahdi B N Am J Med Sci. 2012; 3(3):142-5.

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Consequences of Helicobacter pylori infection in children.

Pacifico L, Anania C, Osborn J, Ferraro F, Chiesa C World J Gastroenterol. 2010; 16(41):5181-94.

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Interleukin 1B proinflammatory genotypes protect against gastro-oesophageal reflux disease through induction of corpus atrophy.

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Update on Therapeutic Options for Helicobacter pylori-related Diseases.

Megraud F Curr Infect Dis Rep. 2005; 7(2):115-120.

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References

Schwizer W, Thumshirn M, Dent J, Guldenschuh I, Menne D, Cathomas G . Helicobacter pylori and symptomatic relapse of gastro-oesophageal reflux disease: a randomised controlled trial. Lancet. 2001; 357(9270):1738-42. DOI: 10.1016/S0140-6736(00)04894-7. View

Labenz J, Malfertheiner P . Helicobacter pylori in gastro-oesophageal reflux disease: causal agent, independent or protective factor?. Gut. 1998; 41(3):277-80. PMC: 1891487. DOI: 10.1136/gut.41.3.277. View

Labenz J . Protagonist: Should we eradicate Helicobacter pylori before long term antireflux therapy?. Gut. 2001; 49(5):614-6. PMC: 1728507. DOI: 10.1136/gut.49.5.614. View

Vakil N, Hahn B, McSorley D . Recurrent symptoms and gastro-oesophageal reflux disease in patients with duodenal ulcer treated for Helicobacter pylori infection. Aliment Pharmacol Ther. 2000; 14(1):45-51. DOI: 10.1046/j.1365-2036.2000.00677.x. View

Koike T, OHara S, Sekine H, Iijima K, Kato K, Shimosegawa T . Helicobacter pylori infection inhibits reflux esophagitis by inducing atrophic gastritis. Am J Gastroenterol. 1999; 94(12):3468-72. DOI: 10.1111/j.1572-0241.1999.01593.x. View

Hamada H, Haruma K, Mihara M, Kamada T, Yoshihara M, Sumii K . High incidence of reflux oesophagitis after eradication therapy for Helicobacter pylori: impacts of hiatal hernia and corpus gastritis. Aliment Pharmacol Ther. 2000; 14(6):729-35. DOI: 10.1046/j.1365-2036.2000.00758.x. View

Malfertheiner P, Megraud F, OMorain C, Hungin A, Jones R, Axon A . Current concepts in the management of Helicobacter pylori infection--the Maastricht 2-2000 Consensus Report. Aliment Pharmacol Ther. 2002; 16(2):167-80. DOI: 10.1046/j.1365-2036.2002.01169.x. View

Labenz J, Tillenburg B, Peitz U, Idstrom J, Verdu E, Stolte M . Helicobacter pylori augments the pH-increasing effect of omeprazole in patients with duodenal ulcer. Gastroenterology. 1996; 110(3):725-32. DOI: 10.1053/gast.1996.v110.pm8608881. View

Manifold D, Anggiansah A, Rowe I, Sanderson J, Chinyama C, Owen W . Gastro-oesophageal reflux and duodenogastric reflux before and after eradication in Helicobacter pylori gastritis. Eur J Gastroenterol Hepatol. 2001; 13(5):535-9. DOI: 10.1097/00042737-200105000-00012. View

10.

Bercik P, Verdu E, Armstrong D, Idstrom J, Cederberg C, Markert M . The effect of ammonia on omeprazole-induced reduction of gastric acidity in subjects with Helicobacter pylori infection. Am J Gastroenterol. 2000; 95(4):947-55. DOI: 10.1111/j.1572-0241.2000.01983.x. View

11.

Blaser M . Hypothesis: the changing relationships of Helicobacter pylori and humans: implications for health and disease. J Infect Dis. 1999; 179(6):1523-30. DOI: 10.1086/314785. View

12.

Malfertheiner P, Dent J, Zeijlon L, Sipponen P, Veldhuyzen van Zanten S, Burman C . Impact of Helicobacter pylori eradication on heartburn in patients with gastric or duodenal ulcer disease -- results from a randomized trial programme. Aliment Pharmacol Ther. 2002; 16(8):1431-42. DOI: 10.1046/j.1365-2036.2002.01285.x. View

13.

Koike T, OHara S, Sekine H, Iijima K, Abe Y, Kato K . Helicobacter pylori infection prevents erosive reflux oesophagitis by decreasing gastric acid secretion. Gut. 2001; 49(3):330-4. PMC: 1728422. DOI: 10.1136/gut.49.3.330. View

14.

Freston J . Antagonist: Should we eradicate Helicobacter pylori before long term antireflux therapy?. Gut. 2001; 49(5):616-7. PMC: 1728514. DOI: 10.1136/gut.49.5.616. View

15.

Verdu E, Armstrong D, Fraser R, Viani F, Idstrom J, Cederberg C . Effect of Helicobacter pylori status on intragastric pH during treatment with omeprazole. Gut. 1995; 36(4):539-43. PMC: 1382493. DOI: 10.1136/gut.36.4.539. View

16.

El-Omar E, Penman I, Dorrian C, Ardill J, McColl K . Eradicating Helicobacter pylori infection lowers gastrin mediated acid secretion by two thirds in patients with duodenal ulcer. Gut. 1993; 34(8):1060-5. PMC: 1374354. DOI: 10.1136/gut.34.8.1060. View

17.

Moayyedi P, Bardhan C, Young L, Dixon M, Brown L, Axon A . Helicobacter pylori eradication does not exacerbate reflux symptoms in gastroesophageal reflux disease. Gastroenterology. 2001; 121(5):1120-6. DOI: 10.1053/gast.2001.29332. View

18.

Malfertheiner P, Gerards C . Helicobacter pylori infection and gastro-oesophageal reflux disease: coincidence or association?. Baillieres Best Pract Res Clin Gastroenterol. 2000; 14(5):731-41. DOI: 10.1053/bega.2000.0121. View

19.

Labenz J, Blum A, Bayerdorffer E, Meining A, Stolte M, Borsch G . Curing Helicobacter pylori infection in patients with duodenal ulcer may provoke reflux esophagitis. Gastroenterology. 1997; 112(5):1442-7. DOI: 10.1016/s0016-5085(97)70024-6. View

20.

Charlett A, Valori R, Uff J, Shepherd N, Barr H, McNulty C . The significance of cagA(+) Helicobacter pylori in reflux oesophagitis. Gut. 2001; 49(3):341-6. PMC: 1728436. DOI: 10.1136/gut.49.3.341. View