Effect of Motilin on Endogenous Release of Insulin in Conscious Dogs in the Fed State

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2004 Jan 13

PMID 14714611

Citations 4

Authors

Hideki Suzuki

Hiroyuki Kuwano

Erito Mochiki

Norihiro Haga

Tatuo Shimura

Kenichi Nomoto

Toshiyuki Tanaka

Akiyoshi Mizumoto

Zen Itoh

Affiliations

Soon will be listed here.

Abstract

The aim was to investigate the insulin-releasing activity of motilin during and after feeding. A single intravenous bolus injection of motilin (0.01-0.3 microg/kg) dose-dependently stimulated endogenous release of insulin in the postprandial state. The insulin-releasing activity of motilin in the fed state was completely abolished by pretreatment with atropine or hexamethonium and was partly inhibited by ondansetron. Truncal vagotomy also greatly suppressed the motilin-induced insulin release. While phentolamine significantly enhanced insulin release in response to motilin, propranolol significantly inhibited this response in both states. The motilin-induced insulin release in the fed states was not accompanied by any changes in glucose concentrations. In conclusion, while the physiological significance remains unclear, these results indicate that physiological doses of motilin stimulate endogenous release of insulin via a vagally cholinergic muscarinic pathway, and that adrenergic and 5-hydroxytryptamine3 receptors are also involved in this response, in the dog.

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