Salt and Salted Food Intake and Subsequent Risk of Gastric Cancer Among Middle-aged Japanese Men and Women

Overview

Journal Br J Cancer

Specialty Oncology

Date 2004 Jan 8

PMID 14710219

Citations 86

Authors

S Tsugane

S Sasazuki

M Kobayashi

S Sasaki

Affiliations

Soon will be listed here.

Abstract

Evidence on the association between salt intake and gastric cancer is sparse, especially in prospective studies. We conducted a population-based prospective study in Japan, where the majority of men has been infected with Helicobacter pylori. A total of 18 684 men and 20 381 women aged 40-59 years who reported their dietary habits and did not report any serious disease at baseline were followed from 1990 to 2001. A total of 486 cases, 358 men and 128 women, with histologically confirmed gastric cancer were documented among them. The quintile category of salt intake was dose-dependently associated with gastric cancer risk in men after adjusting for potential confounding factors (P for trend <0.001), while a trend was not clear in women (P for trend=0.48). Although stratification by study area, with varied salt intake and gastric cancer incidence, attenuated the observed clear associations with salt and salted foods, the frequency categories of highly salted foods such as salted fish roe and salted fish preserves were strongly associated with the risk in both sexes. Restriction of salt and salted food intake is a practical strategy to prevent gastric cancer in areas with high risk.

Citing Articles

Indirect Effects of Municipal Public Health Nurse Workforce on Cancer Standardized Mortality Ratios Mediated by Cancer Screening Rates.

Kodama S, Hinokuma R Public Health Nurs. 2024; 42(1):70-79.

PMID: 39415500 PMC: 11700944. DOI: 10.1111/phn.13451.

Association of Soy Foods With Gastric Cancer Considering : A Multi-Center Case-Control Study.

Nam S, Jeon S, Kwon J, Chung Y, Kwon Y, Lee S J Gastric Cancer. 2024; 24(4):436-450.

PMID: 39375058 PMC: 11471324. DOI: 10.5230/jgc.2024.24.e39.

Health expenditure trajectory and gastric cancer incidence in the National Health Insurance Senior Cohort: a nested case-control study.

Lee W, Yoo K, Noh J, Lee M BMC Health Serv Res. 2024; 24(1):1076.

PMID: 39285469 PMC: 11406828. DOI: 10.1186/s12913-024-11494-y.

Impact of Cardio-Ankle Vascular Index on Future Cancer in Patients With Coronary Artery Disease.

Shimizu T, Sakuma Y, Muto Y, Anzai F, Kimishima Y, Sato Y Circ Rep. 2024; 6(9):372-380.

PMID: 39262639 PMC: 11383543. DOI: 10.1253/circrep.CR-24-0070.

Molecular and cellular basis of sodium sensing in labellum.

Asefa W, Woo J, Kim S, Choi H, Sung H, Choi M iScience. 2024; 27(7):110248.

PMID: 39015148 PMC: 11250893. DOI: 10.1016/j.isci.2024.110248.

References

Watanabe T, Miyasaka M, Koizumi A, Ikeda M . Regional difference in sodium chloride content in home-made and store-bought preparations of miso paste. Tohoku J Exp Med. 1982; 137(3):305-13. DOI: 10.1620/tjem.137.305. View

LAUREN P . THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. Acta Pathol Microbiol Scand. 1965; 64:31-49. DOI: 10.1111/apm.1965.64.1.31. View

Tsugane S, Tei Y, Takahashi T, Watanabe S, Sugano K . Salty food intake and risk of Helicobacter pylori infection. Jpn J Cancer Res. 1994; 85(5):474-8. PMC: 5919501. DOI: 10.1111/j.1349-7006.1994.tb02382.x. View

Taylor D, Blaser M . The epidemiology of Helicobacter pylori infection. Epidemiol Rev. 1991; 13:42-59. DOI: 10.1093/oxfordjournals.epirev.a036078. View

Hoshiyama Y, Sasaba T . A case-control study of stomach cancer and its relation to diet, cigarettes, and alcohol consumption in Saitama Prefecture, Japan. Cancer Causes Control. 1992; 3(5):441-8. DOI: 10.1007/BF00051357. View

Tsugane S, Akabane M, Inami T, Matsushima S, Ishibashi T, Ichinowatari Y . Urinary salt excretion and stomach cancer mortality among four Japanese populations. Cancer Causes Control. 1991; 2(3):165-8. DOI: 10.1007/BF00056209. View

Kneller R, McLaughlin J, BJELKE E, SCHUMAN L, Blot W, Wacholder S . A cohort study of stomach cancer in a high-risk American population. Cancer. 1991; 68(3):672-8. DOI: 10.1002/1097-0142(19910801)68:3<672::aid-cncr2820680339>3.0.co;2-t. View

Huang J, Sridhar S, Chen Y, Hunt R . Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology. 1998; 114(6):1169-79. DOI: 10.1016/s0016-5085(98)70422-6. View

Sasazuki S, Sasaki S, Tsugane S . Cigarette smoking, alcohol consumption and subsequent gastric cancer risk by subsite and histologic type. Int J Cancer. 2002; 101(6):560-6. DOI: 10.1002/ijc.10649. View

10.

Tsugane S, Sasaki S, Kobayashi M, Tsubono Y, Sobue T . Dietary habits among the JPHC study participants at baseline survey. Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Diseases. J Epidemiol. 2002; 11(6 Suppl):S30-43. PMC: 11858369. DOI: 10.2188/jea.11.6sup_30. View

11.

Takahashi M, Hasegawa R . Enhancing effects of dietary salt on both initiation and promotion stages of rat gastric carcinogenesis. Princess Takamatsu Symp. 1985; 16:169-82. View

12.

Tsugane S, Sobue T . Baseline survey of JPHC study--design and participation rate. Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Diseases. J Epidemiol. 2002; 11(6 Suppl):S24-9. PMC: 11858361. DOI: 10.2188/jea.11.6sup_24. View

13.

Blaser M . Helicobacter pylori and the pathogenesis of gastroduodenal inflammation. J Infect Dis. 1990; 161(4):626-33. DOI: 10.1093/infdis/161.4.626. View

14.

Kono S, Hirohata T . Nutrition and stomach cancer. Cancer Causes Control. 1996; 7(1):41-55. DOI: 10.1007/BF00115637. View

15.

JOOSSENS J, Hill M, Elliott P, STAMLER R, Lesaffre E, Dyer A . Dietary salt, nitrate and stomach cancer mortality in 24 countries. European Cancer Prevention (ECP) and the INTERSALT Cooperative Research Group. Int J Epidemiol. 1996; 25(3):494-504. DOI: 10.1093/ije/25.3.494. View

16.

. Diet, nutrition and the prevention of chronic diseases. World Health Organ Tech Rep Ser. 2003; 916:i-viii, 1-149, backcover. View

17.

. Cancer incidence and incidence rates in Japan in 1997: estimates based on data from 12 population-based cancer registries. Jpn J Clin Oncol. 2002; 32(8):318-22. DOI: 10.1093/jjco/hyf062. View

18.

Kobayashi M, Tsubono Y, Sasazuki S, Sasaki S, Tsugane S . Vegetables, fruit and risk of gastric cancer in Japan: a 10-year follow-up of the JPHC Study Cohort I. Int J Cancer. 2002; 102(1):39-44. DOI: 10.1002/ijc.10659. View

19.

Fox J, Dangler C, Taylor N, King A, Koh T, Wang T . High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 mice. Cancer Res. 1999; 59(19):4823-8. View

20.

Tsugane S, Sasaki S, Kobayashi M, Tsubono Y, Akabane M . Validity and reproducibility of the self-administered food frequency questionnaire in the JPHC Study Cohort I: study design, conduct and participant profiles. J Epidemiol. 2003; 13(1 Suppl):S2-12. PMC: 9767693. DOI: 10.2188/jea.13.1sup_2. View