» Articles » PMID: 14703976

Effectiveness of Aloe Vera on the Antioxidant Status of Different Tissues in Irradiated Rats

Overview
Journal Pharmazie
Specialties Pharmacology
Pharmacy
Date 2004 Jan 6
PMID 14703976
Citations 6
Authors
Affiliations
Soon will be listed here.
Abstract

This study was performed to evaluate the role of Aloe vera (Aloe barbadensis Miller) on the antioxidant status in different tissues of animals whole body exposed to 7 Gy gamma radiations, delivered as a shot dose. Aloe vera (leaf juice filtrate) was supplemented daily to rats (0.25 ml/kg body weight/day), by gavage, 5 days before irradiation and 10 days after irradiation. Experimental investigations performed 3, 7 and 10 days after exposure to radiation showed that Aloe vera treatment has significantly minimized the radiation-induced increase in the amount of malondialdehyde in liver, lungs, and kidney tissues of irradiated rats. Significant amelioration in superoxide dismutase (SOD) and catalase activities was observed from the 3rd up to the 10th days for lungs, on the 7th and 10th days for kidneys and at 10 days for liver. Data obtained showed that for the different tissues, improvement in the decrease of reduced glutathione (GSH) contents was obvious on the 10th day after irradiation. Treatment with Aloe vera was also effective in minimizing the radiation-induced increase in plasma glucose levels throughout the experimental period, while it has not ameliorated the increase in plasma insulin levels. It could be concluded that the synergistic relationship between the elements found in the leaf of Aloe vera could be a useful adjunct for maintaining the integrity of the antioxidant status.

Citing Articles

Investigation and Identification of Fungal Diseases of in China.

Zhang G, Wan Q, Li X, Deng J Biology (Basel). 2025; 14(1).

PMID: 39857319 PMC: 11761223. DOI: 10.3390/biology14010089.


Protective Effects of Alpha Lipoic Acid Against Ionizing Radiation- Induced Hepatotoxicity in Rats.

Gezer A, Laloglu A, Kirli Bolukbas M Eurasian J Med. 2023; 55(2):104-108.

PMID: 37403907 PMC: 10440976. DOI: 10.5152/eurasianjmed.2023.0148.


Phenolic Content Analysis of Gel and Evaluation of the Effect of Aloe Gel Supplementation on Oxidative Stress and Fibrosis in Isoprenaline-Administered Cardiac Damage in Rats.

Sumi F, Sikder B, Rahman M, Lubna S, Ulla A, Hossain M Prev Nutr Food Sci. 2019; 24(3):254-264.

PMID: 31608250 PMC: 6779078. DOI: 10.3746/pnf.2019.24.3.254.


Antidiabetic and Antihyperlipidemic Activities of the Leaf Latex Extract of Baker (Aloaceae) in Streptozotocin-Induced Diabetic Model.

Hammeso W, Emiru Y, Getahun K, Kahaliw W Evid Based Complement Alternat Med. 2019; 2019:8263786.

PMID: 31178917 PMC: 6507245. DOI: 10.1155/2019/8263786.


Effect of a bradykinin-potentiating factor isolated from scorpion venom (Leiurus quinquestriatus) on some blood indices and lipid profile in irradiated rats.

Salman M, Kotb A, Haridy M, Golka K, Hammad S Mol Cell Biochem. 2017; 434(1-2):1-6.

PMID: 28391553 DOI: 10.1007/s11010-017-3029-6.