T-cell Control by Human T-cell Leukemia/lymphoma Virus Type 1

Overview

Journal Int J Hematol

Specialty Hematology

Date 2003 Dec 23

PMID 14686485

Citations 31

Authors

Genoveffa Franchini

Risaku Fukumoto

Jake R Fullen

Affiliations

Soon will be listed here.

Abstract

Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) causes neoplastic transformation of human T-cells in a small number of infected individuals several years from infection. Collective evidence from in vitro studies indicates that several viral proteins act in concert to increase the responsiveness of T-cells to extracellular stimulation, modulate proapoptotic and antiapoptotic gene signals, enhance T-cell survival, and avoid immune recognition of the infected T-cells. The virus promotes T-cell proliferation by usurping several signaling pathways central to immune T-cell function, such as antigen stimulation and receptor-ligand interaction, suggesting that extracellular signals are important for HTLV-1 oncogenesis. Environmental factors such as chronic antigen stimulation may therefore be of importance, as also suggested by epidemiological data. Thus genetic and environmental factors together with the virus contribute to disease development. This review focuses on current knowledge of the mechanisms regulating HTLV-1 replication and the T-cell pathways that are usurped by viral proteins to induce and maintain clonal proliferation of infected T-cells. The relevance of these laboratory findings is related to clonal T-cell proliferation and adult T-cell leukemia/lymphoma development in vivo.

Citing Articles

Dynamic Roles of RNA and RNA Epigenetics in HTLV-1 Biology.

King E, Panfil A Viruses. 2025; 17(1).

PMID: 39861913 PMC: 11769288. DOI: 10.3390/v17010124.

Tuning Rex rules HTLV-1 pathogenesis.

Nakano K, Watanabe T Front Immunol. 2022; 13:959962.

PMID: 36189216 PMC: 9523361. DOI: 10.3389/fimmu.2022.959962.

Current Perspectives in Human T-Cell Leukemia Virus Type 1 Infection and Its Associated Diseases.

Miura M, Naito T, Saito M Front Med (Lausanne). 2022; 9:867478.

PMID: 35463007 PMC: 9024061. DOI: 10.3389/fmed.2022.867478.

Elucidation of the Mechanism of Host NMD Suppression by HTLV-1 Rex: Dissection of Rex to Identify the NMD Inhibitory Domain.

Nakano K, Karasawa N, Hashizume M, Tanaka Y, Ohsugi T, Uchimaru K Viruses. 2022; 14(2).

PMID: 35215946 PMC: 8875924. DOI: 10.3390/v14020344.

The contribution of bovines to human health against viral infections.

Saied A, Metwally A, Mohamed H, Haridy M Environ Sci Pollut Res Int. 2021; 28(34):46999-47023.

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