Increased Plasma Thioredoxin in Patients with Acute Myocardial Infarction

Overview

Journal Clin Cardiol

Specialty Cardiology & Vascular Diseases

Date 2003 Dec 18

PMID 14677813

Citations 8

Authors

Hirofumi Soejima

Hisakazu Suefuji

Shinzo Miyamoto

Ichiro Kajiwaram

Sunao Kojima

Jun Hokamaki

Tomohiro Sakamoto

Michihiro Yoshimura

Hajime Nakamura

Junji Yodoi

Hisao Ogawa

Affiliations

Soon will be listed here.

Abstract

Background And Hypothesis: Thioredoxin is an important biomarker for oxidative stress. We investigated whether thioredoxin levels were elevated in patients with acute myocardial infarction (AMI) and were associated with the results of coronary reperfusion.

Methods: The present study determined plasma thioredoxin levels in 51 patients with AMI, 30 patients with stable exertional angina (SEA), and 30 patients with chest pain syndrome (CPS). Plasma sampling was performed on admission, at 12 h, 1 week, 2 weeks, and 4 weeks in patients with AMI, and after admission in patients with SEA and CPS.

Results: Plasma thioredoxin levels on admission were higher in patients with AMI than in those with SEA and CPS. Plasma thioredoxin levels in patients with AMI were decreased in 12 h without further change thereafter. However, thioredoxin levels in patients with AMI remained higher than in those with SEA. In multivariate analysis, higher levels of thioredoxin on admission were a risk factor for failure in emergent reperfusion therapy in patients with AMI independent of other factors.

Conclusion: Plasma thioredoxin levels are elevated in patients with AMI, and higher thioredoxin levels may predict subsequent failed coronary reperfusion therapy in patients with AMI.

Citing Articles

Changing Perspectives from Oxidative Stress to Redox Signaling-Extracellular Redox Control in Translational Medicine.

Palacio P, Godoy J, Aktas O, Hanschmann E Antioxidants (Basel). 2022; 11(6).

PMID: 35740078 PMC: 9228063. DOI: 10.3390/antiox11061181.

Thioredoxin 1 is upregulated in the bone and bone marrow following experimental myocardial infarction: evidence for a remote organ response.

Godoy J, Pittrich S, Slavic S, Lillig C, Hanschmann E, Erben R Histochem Cell Biol. 2020; 155(1):89-99.

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Anti-Inflammatory Thioredoxin Family Proteins for Medicare, Healthcare and Aging Care.

Yodoi J, Matsuo Y, Tian H, Masutani H, Inamoto T Nutrients. 2017; 9(10).

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Cardiac-Secreted Factors as Peripheral Metabolic Regulators and Potential Disease Biomarkers.

Dewey C, Spitler K, Ponce J, Hall D, Grueter C J Am Heart Assoc. 2016; 5(6).

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Serum thioredoxin 1 level has close relation with myocardial damage amount in acute myocardial infarction patients.

Shim Y, Kim J, Seong M, Kim Y, Shim T, Kim S J Korean Med Sci. 2012; 27(10):1162-9.

PMID: 23091312 PMC: 3468751. DOI: 10.3346/jkms.2012.27.10.1162.

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