Inhibitors of CTP Biosynthesis Potentiate the Anti-human Immunodeficiency Virus Type 1 Activity of 3TC in Activated Peripheral Blood Mononuclear Cells

Overview

Journal Antiviral Res

Publisher Elsevier

Date 2003 Dec 13

PMID 14670596

Citations 8

Authors

Nathalie Dereuddre-Bosquet

Beatrice Roy

Kate Routledge

Pascal Clayette

Georges Foucault

Michel Lepoivre

Affiliations

Soon will be listed here.

Abstract

Unlike hydroxyurea, the CTP synthetase inhibitor acivicin and, to a lesser extent, two other inhibitors of CTP synthesis, increased the phosphorylation and anti-HIV-1 activity of 3TC in PHA-P-activated PBMC. These data suggest that to improve the antiretroviral activity of 3TC, it may be worth focusing on inhibition of CTP synthesis.

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