Partially Fluorinated Alkanes As Wash out Solutions After Removal of Silicone Oil Used As an Ocular Endotamponade

Overview

Journal Graefes Arch Clin Exp Ophthalmol

Specialty Ophthalmology

Date 2003 Dec 10

PMID 14663595

Authors

Ulrike Klar-Dissars

Hans Hoerauf

Affiliations

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Abstract

Background: The partially fluorinated alkanes perfluorohexyloctane (F(6)H(8)) and perfluorobutylbutane (O(44 V)) were investigated as wash out solutions after routine silicone oil removal.

Methods: Eleven eyes were rinsed twice with F(6)H(8) immediately after passive silicone oil removal. The silicone oil concentration in both F(6)H(8) samples was measured quantitatively using optical emission spectroscopy (OES). Nine eyes were rinsed twice with O(44 V) immediately after passive silicone oil removal. The silicone oil concentration in both O(44 V) samples was measured quantitatively using OES (n=5) and/or infrared spectroscopy (IR) (n=8).

Results: The mean concentration in the first F(6)H(8) sample was 103.0 ppm, and in the second sample 63.5 ppm using OES. The mean concentration in the first O(44 V) sample was 135.6 ppm, and in the second O(44 V) sample 68.0 ppm using OES.

Conclusion: Since the solubility of silicone oil in F(6)H(8) or O(44 V) is dependent on the temperature and mixture ratio, their use as a routine washout after silicone oil removal in patients without severe emulsification is inefficient. The degree of washout is strongly influenced by surface phenomena and adhesion forces.

References

Meinert H, Roy T . Semifluorinated alkanes--a new class of compounds with outstanding properties for use in ophthalmology. Eur J Ophthalmol. 2000; 10(3):189-97. View

Lucke K, Foerster M, Laqua H . Long-term results of vitrectomy and silicone oil in 500 cases of complicated retinal detachments. Am J Ophthalmol. 1987; 104(6):624-33. DOI: 10.1016/0002-9394(87)90176-0. View

Heimann K, Dimopoulos S, Paulmann H . [Silicone oil injection in the treatment of complicated retinal detachments]. Klin Monbl Augenheilkd. 1984; 185(6):505-8. DOI: 10.1055/s-2008-1054683. View

Hoerauf H, Menz D, Dresp J, Laqua H . Use of O44 as a solvent for silicone oil adhesions on intraocular lenses. J Cataract Refract Surg. 1999; 25(10):1392-3. DOI: 10.1016/s0886-3350(99)00206-0. View

Zeana D, Becker J, Kuckelkorn R, Kirchhof B . Perfluorohexyloctane as a long-term vitreous tamponade in the experimental animal. Experimental perfluorohexyloctane substitution. Int Ophthalmol. 2000; 23(1):17-24. DOI: 10.1023/a:1006444615412. View

Heidenkummer H, Kampik A, Thierfelder S . Experimental evaluation of in vitro stability of purified polydimethylsiloxanes (silicone oil) in viscosity ranges from 1000 to 5000 centistokes. Retina. 1992; 12(3 Suppl):S28-32. DOI: 10.1097/00006982-199212031-00007. View

McCuen 2nd B, de Juan Jr E, Landers 3rd M, MACHEMER R . Silicone oil in vitreoretinal surgery. Part 2: Results and complications. Retina. 1985; 5(4):198-205. DOI: 10.1097/00006982-198500540-00002. View

Langefeld S, Kirchhof B, Meinert H, Roy T, Aretz A, Schrage N . A new way of removing silicone oil from the surface of silicone intraocular lenses. Graefes Arch Clin Exp Ophthalmol. 1999; 237(3):201-6. DOI: 10.1007/s004170050219. View

Bartov E, Pennarola F, Savion N, Naveh N, Treister G . A quantitative in vitro model for silicone oil emulsification. Role of blood constituents. Retina. 1992; 12(3 Suppl):S23-7. DOI: 10.1097/00006982-199212031-00006. View

10.

Hoerauf H, Kobuch K, Dresp J, Menz D . Combined use of partially fluorinated alkanes, perfluorocarbon liquids and silicone oil: an experimental study. Graefes Arch Clin Exp Ophthalmol. 2001; 239(5):373-81. DOI: 10.1007/s004170100264. View

11.

Sell C, McCuen 2nd B, Landers 3rd M, MACHEMER R . Long-term results of successful vitrectomy with silicone oil for advanced proliferative vitreoretinopathy. Am J Ophthalmol. 1987; 103(1):24-8. DOI: 10.1016/s0002-9394(14)74164-9. View

12.

Federman J, Schubert H . Complications associated with the use of silicone oil in 150 eyes after retina-vitreous surgery. Ophthalmology. 1988; 95(7):870-6. DOI: 10.1016/s0161-6420(88)33080-0. View

13.

Kobuch K, Menz I, Hoerauf H, Dresp J, Gabel V . New substances for intraocular tamponades: perfluorocarbon liquids, hydrofluorocarbon liquids and hydrofluorocarbon-oligomers in vitreoretinal surgery. Graefes Arch Clin Exp Ophthalmol. 2001; 239(9):635-42. DOI: 10.1007/s004170100330. View

14.

Hoerauf H, Menz D, Dresp J, Laqua H . [O44--a solvent for silicone oil adhesions on intraocular lenses]. Klin Monbl Augenheilkd. 1999; 214(2):71-6. DOI: 10.1055/s-2008-1034752. View