Lipid Rafts: Heterogeneity on the High Seas

Overview

Journal Biochem J

Specialty Biochemistry

Date 2003 Dec 10

PMID 14662007

Citations 230

Authors

Linda J Pike

Affiliations

Soon will be listed here.

Abstract

Lipid rafts are membrane microdomains that are enriched in cholesterol and glycosphingolipids. They have been implicated in processes as diverse as signal transduction, endocytosis and cholesterol trafficking. Recent evidence suggests that this diversity of function is accompanied by a diversity in the composition of lipid rafts. The rafts in cells appear to be heterogeneous both in terms of their protein and their lipid content, and can be localized to different regions of the cell. This review summarizes the data supporting the concept of heterogeneity among lipid rafts and outlines the evidence for cross-talk between raft components. Based on differences in the ways in which proteins interact with rafts, the Induced-Fit Model of Raft Heterogeneity is proposed to explain the establishment and maintenance of heterogeneity within raft populations.

Citing Articles

Characterizing PFAS hazards and risks: a human population-based in vitro cardiotoxicity assessment strategy.

Ford L, Lin H, Zhou Y, Wright F, Gombar V, Sedykh A Hum Genomics. 2024; 18(1):92.

PMID: 39218963 PMC: 11368000. DOI: 10.1186/s40246-024-00665-x.

Tools shaping drug discovery and development.

Cheung E, Xia Y, Caporini M, Gilmore J Biophys Rev (Melville). 2024; 3(3):031301.

PMID: 38505278 PMC: 10903431. DOI: 10.1063/5.0087583.

Cholesterol-Depletion-Induced Membrane Repair Carries a Raft Conformer of P-Glycoprotein to the Cell Surface, Indicating Enhanced Cholesterol Trafficking in MDR Cells, Which Makes Them Resistant to Cholesterol Modifications.

Gutay-Toth Z, Gellen G, Doan M, Eliason J, Vincze J, Szente L Int J Mol Sci. 2023; 24(15).

PMID: 37569709 PMC: 10419235. DOI: 10.3390/ijms241512335.

Membrane Lipids in Ultra-High-Risk Patients: Potential Predictive Biomarkers of Conversion to Psychosis.

Frajerman A, Chaumette B, Farabos D, Despres G, Simonard C, Lamaziere A Nutrients. 2023; 15(9).

PMID: 37432345 PMC: 10181001. DOI: 10.3390/nu15092215.

The Influence of Lipid Microdomain Heterogeneity on Protein-Protein Interactions: Proteomic Analysis of Co-Immunoprecipitated Binding Partners of P450 1A2 and P450 3A in Rat Liver Microsomes.

Reed J, Guidry J, Eyer M, Backes W Drug Metab Dispos. 2023; 51(9):1196-1206.

PMID: 37349115 PMC: 10449098. DOI: 10.1124/dmd.123.001287.

References

Prior I, Muncke C, Parton R, Hancock J . Direct visualization of Ras proteins in spatially distinct cell surface microdomains. J Cell Biol. 2003; 160(2):165-70. PMC: 2172642. DOI: 10.1083/jcb.200209091. View

Slimane T, Trugnan G, van Ijzendoorn S, Hoekstra D . Raft-mediated trafficking of apical resident proteins occurs in both direct and transcytotic pathways in polarized hepatic cells: role of distinct lipid microdomains. Mol Biol Cell. 2003; 14(2):611-24. PMC: 149996. DOI: 10.1091/mbc.e02-08-0528. View

Panasiewicz M, Domek H, Hoser G, Kawalec M, Pacuszka T . Structure of the ceramide moiety of GM1 ganglioside determines its occurrence in different detergent-resistant membrane domains in HL-60 cells. Biochemistry. 2003; 42(21):6608-19. DOI: 10.1021/bi0206309. View

Nabi I, Le P . Caveolae/raft-dependent endocytosis. J Cell Biol. 2003; 161(4):673-7. PMC: 2199359. DOI: 10.1083/jcb.200302028. View

Rajendran L, Masilamani M, Solomon S, Tikkanen R, Stuermer C, Plattner H . Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells. Proc Natl Acad Sci U S A. 2003; 100(14):8241-6. PMC: 166213. DOI: 10.1073/pnas.1331629100. View

Walmsley A, Zeng F, Hooper N . The N-terminal region of the prion protein ectodomain contains a lipid raft targeting determinant. J Biol Chem. 2003; 278(39):37241-8. DOI: 10.1074/jbc.M302036200. View

Shogomori H, Brown D . Use of detergents to study membrane rafts: the good, the bad, and the ugly. Biol Chem. 2003; 384(9):1259-63. DOI: 10.1515/BC.2003.139. View

Thorn H, Stenkula K, Karlsson M, Ortegren U, Nystrom F, Gustavsson J . Cell surface orifices of caveolae and localization of caveolin to the necks of caveolae in adipocytes. Mol Biol Cell. 2003; 14(10):3967-76. PMC: 206992. DOI: 10.1091/mbc.e03-01-0050. View

Edidin M . The state of lipid rafts: from model membranes to cells. Annu Rev Biophys Biomol Struct. 2003; 32:257-83. DOI: 10.1146/annurev.biophys.32.110601.142439. View

10.

Parton R, Richards A . Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms. Traffic. 2003; 4(11):724-38. DOI: 10.1034/j.1600-0854.2003.00128.x. View

11.

Westover E, Covey D, Brockman H, Brown R, Pike L . Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers. J Biol Chem. 2003; 278(51):51125-33. PMC: 2593805. DOI: 10.1074/jbc.M304332200. View

12.

Singer S, Nicolson G . The fluid mosaic model of the structure of cell membranes. Science. 1972; 175(4023):720-31. DOI: 10.1126/science.175.4023.720. View

13.

OBrien P, Zatz M . Acylation of bovine rhodopsin by [3H]palmitic acid. J Biol Chem. 1984; 259(8):5054-7. View

14.

Roberts W, Myher J, Kuksis A, Low M, Rosenberry T . Lipid analysis of the glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase. Palmitoylation of inositol results in resistance to phosphatidylinositol-specific phospholipase C. J Biol Chem. 1988; 263(35):18766-75. View

15.

ODowd B, Hnatowich M, Caron M, Lefkowitz R, Bouvier M . Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. J Biol Chem. 1989; 264(13):7564-9. View

16.

Hancock J, Magee A, Childs J, Marshall C . All ras proteins are polyisoprenylated but only some are palmitoylated. Cell. 1989; 57(7):1167-77. DOI: 10.1016/0092-8674(89)90054-8. View

17.

Luhrs C, Slomiany B . A human membrane-associated folate binding protein is anchored by a glycosyl-phosphatidylinositol tail. J Biol Chem. 1989; 264(36):21446-9. View

18.

Walter E, Roberts W, Rosenberry T, Ratnoff W, Medof M . Structural basis for variations in the sensitivity of human decay accelerating factor to phosphatidylinositol-specific phospholipase C cleavage. J Immunol. 1990; 144(3):1030-6. View

19.

Rothberg K, Heuser J, Donzell W, Ying Y, Glenney J, Anderson R . Caveolin, a protein component of caveolae membrane coats. Cell. 1992; 68(4):673-82. DOI: 10.1016/0092-8674(92)90143-z. View

20.

Sargiacomo M, Sudol M, Tang Z, Lisanti M . Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells. J Cell Biol. 1993; 122(4):789-807. PMC: 2119592. DOI: 10.1083/jcb.122.4.789. View