Inflammation, Homocysteine, and Vitamin B6 Status After Ischemic Stroke

Overview

Journal Stroke

Specialties Cardiology & Vascular Diseases
Neurology

Date 2003 Dec 6

PMID 14657454

Citations 21

Authors

P J Kelly

J P Kistler

V E Shih

R Mandell

N Atassi

M Barron

H Lee

S Silveira

K L Furie

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Epidemiological studies have described an association between low vitamin B6 (measured as pyridoxal 5'-phosphate [PLP]) and ischemic stroke, independent of homocysteine (tHcy). We investigated B6 status, tHcy, and inflammation (measured by C-reactive protein [CRP]) in patients with stroke and controls.

Methods: Consecutive cases with new ischemic stroke were compared with matched controls. Fasting tHcy, PLP, and CRP were measured.

Results: The adjusted odds ratio of low PLP in the highest compared with the lowest CRP quartile was 16.6 (2, 139.9, P=0.01). Age, CRP, supplemental vitamin use, and albumin were independent predictors of PLP (P<0.05 for all). No relationship was observed between CRP and tHcy.

Conclusions: The relationship between inflammation and low B6 status may partially explain the findings of previous epidemiological studies.

Citing Articles

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