Caspases: an Ancient Cellular Sword of Damocles

Overview

Journal Cell Death Differ

Specialty Cell Biology

Date 2003 Dec 3

PMID 14647235

Citations 35

Authors

M Boyce

A Degterev

J Yuan

Affiliations

Soon will be listed here.

Abstract

Caspases are a family of cysteine proteases homologous to the Caenorhabditis elegans programmed cell death gene product CED-3. Caspases and their distant relatives, meta- and paracaspases, have been found in phylogenetically distant nonmetazoan groups, including plants, fungi and prokaryotes. This review summarizes the current information on the mechanisms and functions of non-mammalian caspases and their relatives in apoptotic and nonapoptotic processes, and explores the possible evolutionary origin of the caspase family.

Citing Articles

Apoptosis-induced translocation of nesprin-2 from the nuclear envelope to mitochondria is associated with mitochondrial dysfunction.

Zohar H, Lindenboim L, Gozlan O, Gundersen G, Worman H, Stein R Nucleus. 2024; 15(1):2413501.

PMID: 39402980 PMC: 11486236. DOI: 10.1080/19491034.2024.2413501.

Characterization of the Apoptotic and Antimicrobial Activities of Two Initiator Caspases of Sea Cucumber .

Zhu H, Yuan Z, Xu H, Sun L Genes (Basel). 2024; 15(5).

PMID: 38790170 PMC: 11121444. DOI: 10.3390/genes15050540.

The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation.

Xu H, Yuan Z, Qin K, Jiang S, Sun L Elife. 2024; 12.

PMID: 38489483 PMC: 10942788. DOI: 10.7554/eLife.89974.

Targeting glutamine dependence with DRP-104 inhibits proliferation and tumor growth of castration-resistant prostate cancer.

Moon D, Hauck J, Jiang X, Quang H, Xu L, Zhang F Prostate. 2023; 84(4):349-357.

PMID: 38084059 PMC: 10872917. DOI: 10.1002/pros.24654.

Green-Based Approach to Synthesize Silver Nanoparticles Using the Fungal Endophyte and Their Antimicrobial, Antioxidant, and Anticancer Potential.

Gupta P, Rai N, Verma A, Saikia D, Singh S, Kumar R ACS Omega. 2022; 7(50):46653-46673.

PMID: 36570288 PMC: 9774420. DOI: 10.1021/acsomega.2c05605.