Modelling the Controls of the Eukaryotic Cell Cycle

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2003 Dec 3

PMID 14641104

Citations 21

Authors

B Novak

J J Tyson

Affiliations

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Abstract

The eukaryotic cell-division cycle is regulated by three modules that control G(1)/S, G(2)/M and meta/anaphase transitions. By using mathematical modelling, we show the dynamic characteristics of these individual modules and we also assemble them together into a comprehensive model of the eukaryotic cell-division cycle. With this comprehensive model, we also discuss the mechanisms by which different checkpoint pathways stabilize different cell-cycle states and inhibit the transitions that drive cell-cycle progression.

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