Expression of Estrogen Receptor Alpha and 17beta-hydroxysteroid Dehydrogenase 4 in the Ciliary Body

Overview

Journal Graefes Arch Clin Exp Ophthalmol

Specialty Ophthalmology

Date 2003 Nov 25

PMID 14634829

Citations 2

Authors

Kaori Kobayashi

Ryo Iwakiri

Hiroshi Kobayashi

Satoshi Okinami

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate the expression and distribution of estrogen receptor alpha (ERalpha) and 17beta-hydroxysteroid dehydrogenase 4 (HSD4) in bovine and monkey ciliary body.

Methods: Immunohistochemical study was employed to investigate the expression of ERalpha and 17beta-HSD4. To detect ERalpha and 17beta-HSD4 transcripts, reverse transcription-polymerase chain reaction (RT-PCR) was used.

Results: In bovine and monkey ciliary body, the staining of the anti-ERalpha antibody was distributed in nonpigmented epithelium, and was not detectable in pigmented epithelium. Vessels in the stroma were also stained. The expression of 17beta-HSD4 was observed in nonpigmented and pigmented epithelium. RT-PCR revealed that the transcripts of ERalpha and 17beta-HSD4 were expressed in monkey ciliary body.

Conclusions: This study provides evidence for the presence of ERalpha and 17beta- HSD4 in the ciliary body. The presence of ERalpha and 17beta-HSD4 suggests that estrogen may have important functions in the ciliary body.

Citing Articles

Estrogen dysregulation, intraocular pressure, and glaucoma risk.

Youngblood H, Schoenlein P, Pasquale L, Stamer W, Liu Y Exp Eye Res. 2023; 237:109725.

PMID: 37956940 PMC: 10842791. DOI: 10.1016/j.exer.2023.109725.

ERalpha increases expression and interacts with TERT in cataractous canine lens epithelial cells.

Colitz C, Sugimoto Y, Lu P, Barden C, Thomas-Ahner J, Chandler H Mol Vis. 2009; 15:2259-67.

PMID: 19936027 PMC: 2776345.

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